Hbegf heparin-binding EGF-like growth factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hbegfprovided by MGI
Official Full Name: heparin-binding EGF-like growth factorprovided by MGI
Primary source: MGI:MGI:96070
See related: Ensembl:ENSMUSG00000024486 AllianceGenome:MGI:96070
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dtr; Dts; Hegfl
Summary: Enables epidermal growth factor receptor binding activity; heparin binding activity; and signaling receptor activator activity. Involved in several processes, including ERBB2 signaling pathway; positive regulation of keratinocyte migration; and wound healing, spreading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of heart contraction. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; heart; submandibular gland primordium; and telencephalon. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 13.0), large intestine adult (RPKM 6.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.46 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (36637980..36648858, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (36504927..36515805, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel IL-4/HB-EGF-dependent crosstalk between eosinophils and macrophages controls liver regeneration after ischaemia and reperfusion injury.
Title: Novel IL-4/HB-EGF-dependent crosstalk between eosinophils and macrophages controls liver regeneration after ischaemia and reperfusion injury.
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.
Title: The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.
An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation.
Title: An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation.
Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages.
Title: Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages.
HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During Otitis Media Induced by a Viral Analog.
Title: HB-EGF Plays a Pivotal Role in Mucosal Hyperplasia During Otitis Media Induced by a Viral Analog.
Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation.
Title: Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation.
Geniposide alleviates choroidal neovascularization by downregulating HB-EGF release from RPE cells by downregulating the miR-145-5p/NF-kappaB axis.
Title: Geniposide alleviates choroidal neovascularization by downregulating HB-EGF release from RPE cells by downregulating the miR-145-5p/NF-κB axis.
Possible effects of pituitary adenylate cyclase activating polypeptide (PACAP) on early embryo implantation marker HB-EGF in mouse.
Title: Possible effects of pituitary adenylate cyclase activating polypeptide (PACAP) on early embryo implantation marker HB-EGF in mouse.
HB-EGF derived exclusively from myeloid cells induces epithelial cell proliferation and EGFR-dependent DNA repair, facilitating pancreas healing after injury.
Title: Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis.
this study shows that HB-EGF ameliorates oxidative stress-mediated uterine decidualization damage
Title: HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (8) 1 citation

General gene information

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Markers

AW047313 (e-PCR)
- UniSTS:181087

Hegfl (e-PCR), detects polymorphism
- UniSTS:233969

Hbegf (e-PCR), detects polymorphism
- UniSTS:516087

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB2-EGFR signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERBB2-ERBB4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in blastocyst growth	TAS Traceable Author Statement more info	PubMed
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of elastin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of elastin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of keratinocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proheparin-binding EGF-like growth factor

Names: diphtheria toxin receptor; heparin binding epidermal growth factor-like growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010415.2 → NP_034545.1 proheparin-binding EGF-like growth factor precursor

Status: VALIDATED

Source sequence(s)

AK145548, AK164309, AW489543

Consensus CDS

CCDS29153.1

UniProtKB/Swiss-Prot

Q06186

UniProtKB/TrEMBL

Q5FW64

Related

ENSMUSP00000025363.6, ENSMUST00000025363.7

Conserved Domains (1) summary

PHA02887
Location:108 → 148

PHA02887; EGF-like protein; Provisional