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    Tor1b torsin family 1, member B [ Mus musculus (house mouse) ]

    Gene ID: 30934, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tor1bprovided by MGI
    Official Full Name
    torsin family 1, member Bprovided by MGI
    Primary source
    MGI:MGI:1353605
    See related
    Ensembl:ENSMUSG00000026848 AllianceGenome:MGI:1353605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DQ1; torsinB; 2610016F05Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within nuclear membrane organization. Located in endoplasmic reticulum lumen and nuclear envelope. Is expressed in several structures, including central nervous system; heart; liver; spleen; and tongue. Orthologous to human TOR1B (torsin family 1 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 17.0), bladder adult (RPKM 14.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tor1b in Genome Data Viewer
    Location:
    2 B; 2 21.76 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30842951..30854085)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30952939..30964073)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene prostaglandin E synthase Neighboring gene predicted gene, 52550 Neighboring gene predicted gene, 57831 Neighboring gene STARR-seq mESC enhancer starr_04126 Neighboring gene peptidylprolyl isomerase A pseudogene 2_387.1 Neighboring gene torsin family 1, member A (torsin A) Neighboring gene cDNA sequence BC005624 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene predicted gene, 39786

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within nuclear membrane organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein localization to nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    torsin-1B
    Names
    torsin ATPase-1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133673.3NP_598434.2  torsin-1B precursor

      See identical proteins and their annotated locations for NP_598434.2

      Status: VALIDATED

      Source sequence(s)
      AK017290, AK028859, AK159843, AV283130
      Consensus CDS
      CCDS15890.1
      UniProtKB/Swiss-Prot
      Q8VEI4, Q9ER41
      Related
      ENSMUSP00000028199.6, ENSMUST00000028199.12
      Conserved Domains (2) summary
      smart00382
      Location:101244
      AAA; ATPases associated with a variety of cellular activities
      cl21455
      Location:51176
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30842951..30854085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318972.3XP_017174461.1  torsin-1B isoform X1

      Conserved Domains (2) summary
      pfam06309
      Location:51176
      Torsin
      TIGR03345
      Location:172227
      VI_ClpV1; type VI secretion ATPase, ClpV1 family

    RNA

    1. XR_374100.2 RNA Sequence

      Related
      ENSMUST00000156711.8