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    Spred1 sprouty protein with EVH-1 domain 1, related sequence [ Mus musculus (house mouse) ]

    Gene ID: 114715, updated on 27-Nov-2024

    Summary

    Official Symbol
    Spred1provided by MGI
    Official Full Name
    sprouty protein with EVH-1 domain 1, related sequenceprovided by MGI
    Primary source
    MGI:MGI:2150016
    See related
    Ensembl:ENSMUSG00000027351 AllianceGenome:MGI:2150016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730461F13Rik
    Summary
    This gene encodes a membrane-associated protein that is phosphorylated by tyrosine kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 12.0), cortex adult (RPKM 10.9) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Spred1 in Genome Data Viewer
    Location:
    2 E5; 2 59.03 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (116951576..117012760)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (117121071..117182279)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39912 Neighboring gene predicted gene, 54145 Neighboring gene STARR-seq mESC enhancer starr_05447 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:116946352-116946601 Neighboring gene STARR-positive B cell enhancer ABC_E3391 Neighboring gene STARR-positive B cell enhancer mm9_chr2:116999459-116999759 Neighboring gene STARR-positive B cell enhancer mm9_chr2:116999814-117000115 Neighboring gene STARR-seq mESC enhancer starr_05449 Neighboring gene microRNA 674 Neighboring gene voltage-dependent anion channel 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables stem cell factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of lens fiber cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vasculogenesis involved in coronary vascular morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasculogenesis involved in coronary vascular morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    sprouty-related, EVH1 domain-containing protein 1
    Names
    sprouty-related protein 1 with EVH-1 domain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277256.2NP_001264185.1  sprouty-related, EVH1 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL807741, AL928959
      Consensus CDS
      CCDS71115.1
      UniProtKB/Swiss-Prot
      Q924S8
      Related
      ENSMUSP00000106526.2, ENSMUST00000110901.2
      Conserved Domains (1) summary
      cd10574
      Location:13125
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    2. NM_033524.4NP_277059.1  sprouty-related, EVH1 domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_277059.1

      Status: VALIDATED

      Source sequence(s)
      AL807741, AL928959
      Consensus CDS
      CCDS16570.1
      UniProtKB/Swiss-Prot
      Q3U2W6, Q6PET8, Q924S8
      Related
      ENSMUSP00000028829.7, ENSMUST00000028829.13
      Conserved Domains (2) summary
      cd10574
      Location:13125
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:333428
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      116951576..117012760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)