Tespa1 thymocyte expressed, positive selection associated 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tespa1provided by MGI
Official Full Name: thymocyte expressed, positive selection associated 1provided by MGI
Primary source: MGI:MGI:1914846
See related: Ensembl:ENSMUSG00000034833 AllianceGenome:MGI:1914846
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Itprid3; 5830405N20Rik; A430001F24Rik
Summary: Enables phospholipase binding activity. Involved in several processes, including COP9 signalosome assembly; positive regulation of T cell differentiation in thymus; and positive regulation of T cell receptor signaling pathway. Acts upstream of or within TCR signalosome assembly. Located in cytoplasm. Part of TCR signalosome. Is expressed in ductus deferens; testis; thymus; and thymus primordium. Orthologous to human TESPA1 (thymocyte expressed, positive selection associated 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 15.0), spleen adult (RPKM 3.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.85 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (130158696..130199338)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (130322826..130363469)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation.
Title: Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation.
Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.
Title: Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.
Thymic-specific regulation of TCR signaling by Tespa1.
Title: Thymic-specific regulation of TCR signaling by Tespa1.
Our study demonstrates that Tespa1 is essential for T cell-dependent B cell responses, and suggests an important role for Tespa1 during the development of autoimmune arthritis.
Title: Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and Attenuates Collagen-Induced Arthritis in Mice.
Tespa1 functions in T cell development and the regulation of TCR-induced Ca(2+) signalling through IP3R1
Title: Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.
Loss of Tespa1 in mouse mast cells led to hyper-responsiveness to stimulation via FcepsilonRI.
Title: Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
Tespa1 is post-translationally modified upon intracellular Ca2+ increase in thymocytes.
Title: Tespa1 protein is phosphorylated in response to store-operated calcium entry.
Tespa1 is a component of the TCR signalosome and is essential for T-cell selection and maturation through regulation of TCR signaling during T-cell development.
Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in COP9 signalosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell differentiation in thymus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within TCR signalosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
part_of COP9 signalosome	ISS Inferred from Sequence or Structural Similarity more info
part_of TCR signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of TCR signalosome	IMP Inferred from Mutant Phenotype more info	PubMed
part_of TCR signalosome	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein TESPA1

Names: thymocyte-expressed positive selection-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429520.1 → NP_001416449.1 protein TESPA1 isoform a

Status: VALIDATED

Source sequence(s)

AC152977, AC159473

UniProtKB/Swiss-Prot

Q3TR68, Q3U132, Q8CEN9
NM_001429521.1 → NP_001416450.1 protein TESPA1 isoform a

Status: VALIDATED

Source sequence(s)

AC152977, AC159473

UniProtKB/Swiss-Prot

Q3TR68, Q3U132, Q8CEN9
NM_001429522.1 → NP_001416451.1 protein TESPA1 isoform a

Status: VALIDATED

Source sequence(s)

AC152977, AC159473

UniProtKB/Swiss-Prot

Q3TR68, Q3U132, Q8CEN9
NM_001429523.1 → NP_001416452.1 protein TESPA1 isoform a

Status: VALIDATED

Source sequence(s)

AC152977, AC159473

UniProtKB/Swiss-Prot

Q3TR68, Q3U132, Q8CEN9
NM_001429524.1 → NP_001416453.1 protein TESPA1 isoform b

Status: VALIDATED

Source sequence(s)

AC159473
NM_001429525.1 → NP_001416454.1 protein TESPA1 isoform c

Status: VALIDATED

Source sequence(s)

AC152977, AC159473
NM_001429526.1 → NP_001416455.1 protein TESPA1 isoform c

Status: VALIDATED

Source sequence(s)

AC152977, AC159473
NM_001429527.1 → NP_001416456.1 protein TESPA1 isoform d

Status: VALIDATED

Source sequence(s)

AC152977, AC159473
NM_183264.5 → NP_899087.2 protein TESPA1 isoform a

See identical proteins and their annotated locations for NP_899087.2

Status: VALIDATED

Source sequence(s)

AC152977, AC159473

Consensus CDS

CCDS48735.1

UniProtKB/Swiss-Prot

Q3TR68, Q3U132, Q8CEN9

Related

ENSMUSP00000047284.9, ENSMUST00000042586.10

Conserved Domains (1) summary

pfam14722
Location:130 → 251

KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

130158696..130199338

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514006.4 → XP_006514069.1 protein TESPA1 isoform X1

Conserved Domains (1) summary

pfam14722
Location:130 → 251

KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain