SCO2 putative thioredoxin peroxidase SCO2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SCO2
Official Full Name: putative thioredoxin peroxidase SCO2
Primary source: SGD:S000000228
Locus tag: YBR024W
See related: AllianceGenome:SGD:S000000228; FungiDB:YBR024W; VEuPathDB:YBR024W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables copper ion binding activity. Involved in cell redox homeostasis and cellular response to oxidative stress. Located in mitochondrial membrane. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease and mitochondrial complex IV deficiency nuclear type 4. Orthologous to human SCO1 (synthesis of cytochrome C oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

we found that simultaneous deletion of Coa6 and Sco2 completely abrogates Cox2 biogenesis.
Title: Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables copper chaperone activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular copper ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in respiratory chain complex IV assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_009580.1

Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain