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    PEX34 Pex34p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850302, updated on 17-Dec-2024

    Summary

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    Official Symbol
    PEX34
    Official Full Name
    Pex34p
    Primary source
    SGD:S000000561
    Locus tag
    YCL056C
    See related
    AllianceGenome:SGD:S000000561; FungiDB:YCL056C; VEuPathDB:YCL056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables peroxisome-mitochondrion membrane tether activity. Involved in peroxisome organization. Located in peroxisomal membrane. Is active in peroxisomal-mitochondrial contact site. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PEX34 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (26925..27359, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Mic10p Neighboring gene metalloendopeptidase Neighboring gene Kar4p Neighboring gene Rdt1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of peroxisomes in xylose alcoholic fermentation in the engineered Saccharomyces cerevisiae. Dzanaeva L, et al. Cell Biol Int, 2020 Aug. PMID 32227552
    2. The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast. Tower RJ, et al. Mol Biol Cell, 2011 May 15. PMID 21441307, Free PMC Article
    3. Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p. Chalermwat C, et al. FEMS Yeast Res, 2019 Dec 1. PMID 31711143, Free PMC Article
    4. Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact. Shai N, et al. Nat Commun, 2018 May 2. PMID 29720625, Free PMC Article
    5. Genetic Analysis of Peroxisomal Genes Required for Longevity in a Yeast Model of Citrin Deficiency. Chalermwat C, et al. Diseases, 2020 Jan 9. PMID 31936501, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p
      Title: Overexpression of the peroxin Pex34p suppresses impaired acetate utilization in yeast lacking the mitochondrial aspartate/glutamate carrier Agc1p.
    2. discovery of Pex34p as a protein involved in the already complex control of peroxisome populations emphasizes the necessity of cells to strictly regulate their peroxisome populations. [pex34p]
      Title: The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables peroxisome-mitochondrion membrane tether activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal-mitochondrial contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pex34p
    NP_009875.1
    • Protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation; mediates contacts between mitochondria and peroxisomes that stimulate transport of citrate, converted from acetyl-CoA, from peroxisomes to mitochondria; peroxisomal integral membrane protein that is enriched at peroxisomal-mitochondrial (PerMit) contact sites

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      26925..27359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178700.1 → NP_009875.1  TPA: Pex34p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQW1, P25584
      UniProtKB/TrEMBL
      A6ZTD9, B3LU29, C7GT10, C8Z435, G2W9X2, N1P7P2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25584.1

    Gene LinkOut

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