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    ATG31 Atg31p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851585, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATG31
    Official Full Name
    Atg31p
    Primary source
    SGD:S000002429
    Locus tag
    YDR022C
    See related
    AllianceGenome:SGD:S000002429; FungiDB:YDR022C; VEuPathDB:YDR022C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CIS1
    Summary
    Involved in autophagy of mitochondrion and piecemeal microautophagy of the nucleus. Located in phagophore assembly site. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATG31 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (488072..488662, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative uridine kinase DAS2 Neighboring gene ATP-dependent RNA helicase FAL1 Neighboring gene tRNA-Val Neighboring gene serine--tRNA ligase SES1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of Atg31 is required for autophagy. Feng W, et al. Protein Cell, 2015 Apr. PMID 25773276, Free PMC Article
    2. Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae. Kabeya Y, et al. Biochem Biophys Res Commun, 2007 May 4. PMID 17362880
    3. Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Kabeya Y, et al. Biochem Biophys Res Commun, 2009 Nov 27. PMID 19755117
    4. Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29. Chew LH, et al. Autophagy, 2013 Oct. PMID 23939028, Free PMC Article
    5. Scaffolding the cup-shaped double membrane in autophagy. Bahrami AH, et al. PLoS Comput Biol, 2017 Oct. PMID 29065154, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of Atg31 is required for autophagy.
      Title: Phosphorylation of Atg31 is required for autophagy.
    2. Atg17 adopts multiple conformations in the absence of Atg31 and Atg29 suggests that the two smaller components play key roles in defining and maintaining the distinct curvature of the ternary complex
      Title: Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29.
    3. single-particle electron microscopy analysis of the Atg17-Atg31-Atg29 complex reveals an elongated structure with Atg29 located at the opposing ends.
      Title: Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.
    4. Atg17-Atg29-Atg31 ternary complex acts as a functional unit for autophagosome formation.
      Title: Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in karyogamy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Atg31p
    NP_010305.1
    • Autophagy-specific protein required for autophagosome formation; forms a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; constitutively phosphorylated, and phosphorylation of residue S174 is required for function; high-copy suppressor of CIK1 deletion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      488072..488662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180330.1 → NP_010305.1  TPA: Atg31p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010305.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS08, Q03939, Q12421
      UniProtKB/TrEMBL
      A6ZXY6, B3LGP2, C8Z4U2, N1P7Z6
      Conserved Domains (1) summary
      pfam09795
      Location:2 → 196
      Atg31; Autophagy-related protein 31
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12421.1

    Gene LinkOut

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