Kat6a lysine acetyltransferase 6A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kat6aprovided by RGD
Official Full Name: lysine acetyltransferase 6Aprovided by RGD
Primary source: RGD:1304892
See related: EnsemblRapid:ENSRNOG00000025174 AllianceGenome:RGD:1304892
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Moz; Myst3; Znf220; Runxbp2
Summary: Predicted to enable several functions, including histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Involved in positive regulation of gene expression. Predicted to be located in chromatin; cytosol; and nuclear lumen. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Arboleda-Tham syndrome and acute myeloid leukemia. Orthologous to human KAT6A (lysine acetyltransferase 6A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 165.5), Lung (RPKM 149.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (75787411..75868584, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (69084914..69165923, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (73942669..74020750, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

during early hepatocarcinogenesis, aberrantly expressed MOZ may induce glutathione S-transferase placental form expression through the Nrf2-mediated pathway
Title: Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

Myst3 (e-PCR), detects polymorphism
- UniSTS:516610

Myst3 (e-PCR), detects polymorphism
- UniSTS:516612

RH140730 (e-PCR)
- UniSTS:222796

D1S3688 (e-PCR)
- UniSTS:474266

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K14 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K5 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aorta morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MOZ/MORF histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of MOZ/MORF histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histone acetyltransferase KAT6A

Names: K(lysine) acetyltransferase 6A; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; MYST protein 3; MYST-3; histone acetyltransferase MYST3; monocytic leukemia zinc finger homolog; monocytic leukemia zinc finger protein

NP_001094040.1

EC 2.3.1.48

XP_038950514.1

EC 2.3.1.48

XP_038950515.1

EC 2.3.1.48

XP_063131525.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100570.4 → NP_001094040.1 histone acetyltransferase KAT6A

See identical proteins and their annotated locations for NP_001094040.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q5TKR9

UniProtKB/TrEMBL

A0A0G2K1C6, A6IW49

Related

ENSRNOP00000071789.2, ENSRNOT00000078743.3

Conserved Domains (4) summary

smart00526
Location:85 → 162

H15; Domain in histone families 1 and 5

PLN00104
Location:502 → 776

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:264 → 310

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:205 → 262

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

75787411..75868584 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094586.2 → XP_038950514.1 histone acetyltransferase KAT6A isoform X1

UniProtKB/Swiss-Prot

Q5TKR9

UniProtKB/TrEMBL

A0A0G2K1C6, A6IW49

Conserved Domains (4) summary

smart00526
Location:85 → 162

H15; Domain in histone families 1 and 5

PLN00104
Location:502 → 776

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:264 → 310

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:205 → 262

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_039094587.2 → XP_038950515.1 histone acetyltransferase KAT6A isoform X1

UniProtKB/Swiss-Prot

Q5TKR9

UniProtKB/TrEMBL

A0A0G2K1C6, A6IW49

Conserved Domains (4) summary

smart00526
Location:85 → 162

H15; Domain in histone families 1 and 5

PLN00104
Location:502 → 776

PLN00104; MYST -like histone acetyltransferase; Provisional

cd15527
Location:264 → 310

PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

cd15618
Location:205 → 262

PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
XM_063275455.1 → XP_063131525.1 histone acetyltransferase KAT6A isoform X2