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    Pou6f1 POU class 6 homeobox 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116545, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pou6f1provided by RGD
    Official Full Name
    POU class 6 homeobox 1provided by RGD
    Primary source
    RGD:620615
    See related
    EnsemblRapid:ENSRNOG00000070769 AllianceGenome:RGD:620615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Brn5
    Summary
    Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in actin cytoskeleton and nuclear body. Orthologous to human POU6F1 (POU class 6 homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 35.1), Kidney (RPKM 25.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pou6f1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133556506..133580004, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131677719..131700869, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142201614..142225256, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine and serine rich nuclear protein 2 Neighboring gene transcription factor CP2 Neighboring gene uncharacterized LOC120093736 Neighboring gene uncharacterized LOC134479579 Neighboring gene uncharacterized LOC134479580

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General protein information

    Preferred Names
    POU domain, class 6, transcription factor 1
    Names
    brain-5
    brain-specific homeobox/POU domain protein 5
    brn-5 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105746.1NP_001099216.1  POU domain, class 6, transcription factor 1

      See identical proteins and their annotated locations for NP_001099216.1

      Status: VALIDATED

      Source sequence(s)
      CH474035
      UniProtKB/Swiss-Prot
      P56223
      UniProtKB/TrEMBL
      A6KCK3
      Conserved Domains (3) summary
      PRK14950
      Location:23155
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam00046
      Location:237291
      Homeobox; Homeobox domain
      cl22952
      Location:139213
      Pou; Pou domain - N-terminal to homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      133556506..133580004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078246.2XP_038934174.1  POU domain, class 6, transcription factor 1 isoform X3

      Conserved Domains (3) summary
      smart00352
      Location:449523
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:41426
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:547601
      Homeobox; Homeobox domain
    2. XM_039078243.2XP_038934171.1  POU domain, class 6, transcription factor 1 isoform X1

      Conserved Domains (3) summary
      smart00352
      Location:453527
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:45430
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:551605
      Homeobox; Homeobox domain
    3. XM_039078244.2XP_038934172.1  POU domain, class 6, transcription factor 1 isoform X1

      Conserved Domains (3) summary
      smart00352
      Location:453527
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:45430
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:551605
      Homeobox; Homeobox domain
    4. XM_039078245.2XP_038934173.1  POU domain, class 6, transcription factor 1 isoform X2

      Related
      ENSRNOP00000080135.2, ENSRNOT00000100238.3
      Conserved Domains (3) summary
      smart00352
      Location:452526
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:52429
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:550604
      Homeobox; Homeobox domain
    5. XM_063262865.1XP_063118935.1  POU domain, class 6, transcription factor 1 isoform X3

    6. XM_063262864.1XP_063118934.1  POU domain, class 6, transcription factor 1 isoform X1

    7. XM_039078248.2XP_038934176.1  POU domain, class 6, transcription factor 1 isoform X6

      Conserved Domains (3) summary
      smart00352
      Location:415489
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:49392
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:513567
      Homeobox; Homeobox domain
    8. XM_063262866.1XP_063118936.1  POU domain, class 6, transcription factor 1 isoform X7

    9. XM_017594569.3XP_017450058.1  POU domain, class 6, transcription factor 1 isoform X5

      UniProtKB/Swiss-Prot
      P56223
      UniProtKB/TrEMBL
      A6KCK3
      Conserved Domains (3) summary
      PRK14950
      Location:23155
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam00046
      Location:237291
      Homeobox; Homeobox domain
      cl22952
      Location:139213
      Pou; Pou domain - N-terminal to homeobox domain
    10. XM_039078247.2XP_038934175.1  POU domain, class 6, transcription factor 1 isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:63309
      PHA03247; large tegument protein UL36; Provisional
      PRK07994
      Location:175277
      PRK07994; DNA polymerase III subunits gamma and tau; Validated

    RNA

    1. XR_010052928.1 RNA Sequence