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    SSF2 rRNA-binding ribosome biosynthesis protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851907, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SSF2
    Official Full Name
    rRNA-binding ribosome biosynthesis protein
    Primary source
    SGD:S000002720
    Locus tag
    YDR312W
    See related
    AllianceGenome:SGD:S000002720; FungiDB:YDR312W; VEuPathDB:YDR312W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA binding activity. Involved in ribosomal large subunit assembly. Located in nucleolus. Orthologous to human PPAN-P2RY11 (PPAN-P2RY11 readthrough) and PPAN (peter pan homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SSF2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1087581..1088942)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Sum1p Neighboring gene TFIIH/NER complex subunit TFB1 Neighboring gene phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase Neighboring gene Rad34p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nucleolar protein that affects mating efficiency in Saccharomyces cerevisiae by altering the morphological response to pheromone. Kim J, et al. Genetics, 1998 Jun. PMID 9611192, Free PMC Article
    2. An essential gene pair in Saccharomyces cerevisiae with a potential role in mating. Yu Y, et al. DNA Cell Biol, 1995 May. PMID 7748491
    3. Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1. Guo X, et al. Appl Microbiol Biotechnol, 2020 Sep. PMID 32715361
    4. A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR. Dhillon N, et al. Mol Cell, 2000 Oct. PMID 11090616
    5. Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes. Bogengruber E, et al. FEMS Yeast Res, 2003 Mar. PMID 12702244

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
      Title: Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rRNA-binding ribosome biosynthesis protein
    NP_010598.3
    • Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1087581..1088942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180620.3 → NP_010598.3  TPA: rRNA-binding ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010598.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSU1, Q12153
      UniProtKB/TrEMBL
      A6ZYR0, B3LFY4, C8Z5M3, N1P581
      Conserved Domains (1) summary
      smart00879
      Location:26 → 220
      Brix; The Brix domain is found in a number of eukaryotic proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12153.1

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