Kptn kaptin (actin binding protein) [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Kptnprovided by RGD
Full Name: kaptin (actin binding protein)provided by RGD
Primary source: RGD:1310341
See related: AllianceGenome:RGD:1310341
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kptnl1
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; cellular response to glucose starvation; and negative regulation of TORC1 signaling. Predicted to be located in lamellipodium and postsynaptic actin cytoskeleton. Predicted to be part of KICSTOR complex and filamentous actin. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 41. Orthologous to human KPTN (kaptin, actin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 74.2), Brain (RPKM 65.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (85936922..85937716)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (76808737..76809531)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78015714..78016508)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to lysosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of KICSTOR complex	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: KICSTOR complex protein kaptin

Names: kaptin-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.