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    Ncf4 neutrophil cytosolic factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500904, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ncf4provided by RGD
    Official Full Name
    neutrophil cytosolic factor 4provided by RGD
    Primary source
    RGD:1593157
    See related
    EnsemblRapid:ENSRNOG00000006940 AllianceGenome:RGD:1593157
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to be located in cytosol and endosome membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 3 and rheumatoid arthritis. Orthologous to human NCF4 (neutrophil cytosolic factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 99.4), Lung (RPKM 35.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncf4 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111705926..111723893)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109825420..109843389)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119481711..119499426)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 27 Neighboring gene parvalbumin Neighboring gene colony stimulating factor 2 receptor subunit beta Neighboring gene ciliary microtubule inner protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. Bravo J, et al. Mol Cell, 2001 Oct. PMID 11684018
    2. A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity. Olsson LM, et al. Arthritis Res Ther, 2007. PMID 17897462, Free PMC Article
    3. A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma. Ansari MA, et al. Free Radic Biol Med, 2014 Dec. PMID 25224032, Free PMC Article
    4. p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains. Wientjes FB, et al. Biochem J, 1993 Dec 15. PMID 8280052, Free PMC Article
    5. Identification of non-mitochondrial NADPH oxidase and the spatio-temporal organization of its components in mouse spermatozoa. Shukla S, et al. Biochem Biophys Res Commun, 2005 Jun 3. PMID 15850784

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The levels of cytosolic p67Phox, p47Phox, and p40Phox were increased in membrane fractions following traumatic brain injury.
      Title: A time course of NADPH-oxidase up-regulation and endothelial nitric oxide synthase activation in the hippocampus following neurotrauma.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables superoxide-generating NADPH oxidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables superoxide-generating NADPH oxidase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory burst IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NADPH oxidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neutrophil cytosol factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127304.1 → NP_001120776.1  neutrophil cytosol factor 4

      See identical proteins and their annotated locations for NP_001120776.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A0A8I5ZNF3, A0A9K3Y7E3, B2RZ98, D3ZS40
      Related
      ENSRNOP00000009544.6, ENSRNOT00000009544.8
      Conserved Domains (3) summary
      cd06399
      Location:238 → 329
      PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
      cd06882
      Location:19 → 141
      PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
      cd11869
      Location:174 → 227
      SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      111705926..111723893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241939.5 → XP_006242001.1  neutrophil cytosol factor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNF3
      Related
      ENSRNOP00000110351.1, ENSRNOT00000142103.1
      Conserved Domains (3) summary
      cd06399
      Location:254 → 345
      PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
      cd06882
      Location:56 → 157
      PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
      cd11869
      Location:190 → 243
      SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase
    Nucleotide Protein Strain
    Heading Accession and Version

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