MNN1 alpha-1,3-mannosyltransferase MNN1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MNN1
Official Full Name: alpha-1,3-mannosyltransferase MNN1
Primary source: SGD:S000000803
Locus tag: YER001W
See related: AllianceGenome:SGD:S000000803; FungiDB:YER001W; VEuPathDB:YER001W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables alpha-1,3-mannosyltransferase activity. Involved in N-glycan processing and protein O-linked glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MNN1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (153520..155808)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ybl006c (Rsc14) controls expression of MNN6, MNN4 and MNN1
Title: Rsc14-controlled expression of MNN6, MNN4 and MNN1 regulates mannosylphosphorylation of Saccharomyces cerevisiae cell wall mannoproteins.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha-1,3-mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,3-mannosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-glycan processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-1,3-mannosyltransferase MNN1

NP_010916.1

Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides; one of five S. cerevisiae proteins of MNN1 family; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

153520..155808

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178892.1 → NP_010916.1 TPA: alpha-1,3-mannosyltransferase MNN1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010916.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLP7, P39106

UniProtKB/TrEMBL

N1P5F1

Conserved Domains (1) summary

pfam11051
Location:317 → 613

Mannosyl_trans3; Mannosyltransferase putative