U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Wdr44 WD repeat domain 44 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246152, updated on 27-Nov-2024

    Summary

    Official Symbol
    Wdr44provided by RGD
    Official Full Name
    WD repeat domain 44provided by RGD
    Primary source
    RGD:727965
    See related
    EnsemblRapid:ENSRNOG00000029068 AllianceGenome:RGD:727965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rab11BP
    Summary
    Enables small GTPase binding activity. Involved in regulation of cell migration. Located in microtubule and perinuclear region of cytoplasm. Orthologous to human WDR44 (WD repeat domain 44). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 91.0), Thymus (RPKM 86.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Wdr44 in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (119286802..119392240)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (114481890..114587307)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (120860178..120965918)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120099301 Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular sequestering activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cytosolic ciliogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytosolic ciliogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 44
    Names
    WD-containing protein Rab11BP/Rabphilin-11
    rabphilin-11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100823.1NP_001094293.1  WD repeat-containing protein 44

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2JX77, A6JMD4
      Related
      ENSRNOP00000047275.5, ENSRNOT00000040742.6
      Conserved Domains (3) summary
      COG2319
      Location:499825
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:516607
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:512859
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      119286802..119392240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099449.2XP_038955377.1  WD repeat-containing protein 44 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7S6, A6JMD4
      Conserved Domains (2) summary
      sd00039
      Location:520611
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:516863
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_063279776.1XP_063135846.1  WD repeat-containing protein 44 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JX77
    3. XM_039099450.2XP_038955378.1  WD repeat-containing protein 44 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7S6, A6JMD4
      Related
      ENSRNOP00000074327.2, ENSRNOT00000088661.3
      Conserved Domains (2) summary
      sd00039
      Location:520611
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:516863
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...