HCR1 translation initiation factor eIF3 core subunit j [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HCR1
Official Full Name: translation initiation factor eIF3 core subunit j
Primary source: SGD:S000004182
Locus tag: YLR192C
See related: AllianceGenome:SGD:S000004182; FungiDB:YLR192C; VEuPathDB:YLR192C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables translation initiation factor activity. Involved in cytoplasmic translation and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Acts upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in cytoplasmic stress granule. Part of eukaryotic translation initiation factor 3 complex. Orthologous to human EIF3J (eukaryotic translation initiation factor 3 subunit J). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HCR1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (538792..539589, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hcr1/eIF3j Is a 60S Ribosomal Subunit Recycling Accessory Factor In Vivo.
Title: Hcr1/eIF3j Is a 60S Ribosomal Subunit Recycling Accessory Factor In Vivo.
Based on these and other observations we suggest that the assignment of HCR1 as a bona fide eIF3 subunit should be reconsidered.
Title: Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells.
Data suggest that the eIF3b-eIF3j/eIF3a module binds near the mRNA entry channel and regulates the transition between scanning-conducive and initiation-competent conformations of the preinitiation complex.
Title: The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.
although the Fe-S cluster is not required for the interaction of Rli1 with eRF1 or its other interacting partner, Hcr1, from the initiation complex eIF3, it is required for its activity in translation termination
Title: The iron-sulphur protein RNase L inhibitor functions in translation termination.
eIF3j/HCR1 remains associated with the scanning preinitiation complexes and does not dissociate from the small ribosomal subunit upon mRNA recruitment, as previously believed
Title: The indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selection.
Interaction of the RNP1 motif with HCR1 promotes 40S binding of eIF3.
Title: Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IPI Inferred from Physical Interaction more info	PubMed
involved_in cytoplasmic translational initiation	IEA Inferred from Electronic Annotation more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: translation initiation factor eIF3 core subunit j

NP_013293.1

eIF3j component of translation initiation factor 3 (eIF3); role in initiation as a substoichiometric component of eIF3; 60S ribosomal subunit recycling accessory factor; involved in nonsense-mediated mRNA decay (NMD); required for 20S pre-rRNA processing; post-transcriptional role in retrotransposition; absence decreases Ty1 Gag protein levels; binds eIF3 subunits Rpg1p, Prt1p and 18S rRNA; eIF3 promotes programmed stop codon readthrough; human homolog EIF3J can complement a yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

538792..539589 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182079.1 → NP_013293.1 TPA: translation initiation factor eIF3 core subunit j [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013293.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYJ5, Q05775

UniProtKB/TrEMBL

A7A182, B3RH83, B5VNB1, C7GIX9, C8ZDF9, G2WJ24, N1NZS9

Conserved Domains (1) summary

pfam08597
Location:2 → 215

eIF3_subunit; Translation initiation factor eIF3 subunit