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    SDH2 succinate dehydrogenase iron-sulfur protein subunit SDH2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDH2
    Official Full Name
    succinate dehydrogenase iron-sulfur protein subunit SDH2
    Primary source
    SGD:S000003964
    Locus tag
    YLL041C
    See related
    AllianceGenome:SGD:S000003964; FungiDB:YLL041C; VEuPathDB:YLL041C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ACN17
    Summary
    Enables succinate dehydrogenase (quinone) activity. Involved in tricarboxylic acid cycle. Located in mitochondrial membrane. Part of respiratory chain complex II (succinate dehydrogenase). Used to study mitochondrial encephalomyopathy and paraganglioma. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDH2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (53131..53931, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fps1p Neighboring gene E2-like conjugating enzyme Neighboring gene membrane morphogenesis protein VPS13 Neighboring gene ubiquitin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of glucose regulation in saccharomyces cerevisiae: control of transcription versus mRNA turnover. Cereghino GP, et al. EMBO J, 1996 Jan 15. PMID 8617211, Free PMC Article
    2. The role of the 5' untranslated region (UTR) in glucose-dependent mRNA decay. de la Cruz BJ, et al. Yeast, 2002 Jul. PMID 12112242
    3. Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor. Goffrini P, et al. Hum Mol Genet, 2009 May 15. PMID 19261679
    4. Glucose-dependent turnover of the mRNAs encoding succinate dehydrogenase peptides in Saccharomyces cerevisiae: sequence elements in the 5' untranslated region of the Ip mRNA play a dominant role. Cereghino GP, et al. Mol Biol Cell, 1995 Sep. PMID 8534911, Free PMC Article
    5. Studies on the assembly of complex II in yeast mitochondria using chimeric human/yeast genes for the iron-sulfur protein subunit. Saghbini M, et al. Biochemistry, 1994 Jan 11. PMID 8286334

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate dehydrogenase (quinone) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables succinate dehydrogenase (quinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular respiration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex II (succinate dehydrogenase) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinate dehydrogenase iron-sulfur protein subunit SDH2
    NP_013059.1
    • Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      53131..53931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181861.1 → NP_013059.1  TPA: succinate dehydrogenase iron-sulfur protein subunit SDH2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013059.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXW5, P21801
      UniProtKB/TrEMBL
      A7A0L7, B3LTD3, B5VMQ7, C7GRK0, C8ZCT3, G2WIF6, N1NZC0
      Conserved Domains (1) summary
      PLN00129
      Location:31 → 264
      PLN00129; succinate dehydrogenase [ubiquinone] iron-sulfur subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21801.1

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