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    putative amidotransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850817, updated on 9-Dec-2024

    Summary

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    Official Full Name
    putative amidotransferase
    Primary source
    SGD:S000004116
    Locus tag
    YLR126C
    See related
    AllianceGenome:SGD:S000004116; FungiDB:YLR126C; VEuPathDB:YLR126C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transferase activity. Predicted to be involved in intracellular monoatomic cation homeostasis. Located in nuclear periphery. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (394765..395520, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene anaphase promoting complex subunit 2 Neighboring gene NEDD8 ligase DCN1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption and functional analysis of six ORFs on chromosome XII of saccharomyces cerevisiae: YLR124w, YLR125w, YLR126c, YLR127c, YLR128w and YLR129w. Willer M, et al. Yeast, 2000 Nov. PMID 11054824
    2. Exploratory and confirmatory gene expression profiling of mac1Delta. De Freitas JM, et al. J Biol Chem, 2004 Feb 6. PMID 14534306
    3. Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications. Nitika, et al. PLoS Biol, 2022 Oct. PMID 36269765, Free PMC Article
    4. Functional analysis with a barcoder yeast gene overexpression system. Douglas AC, et al. G3 (Bethesda), 2012 Oct. PMID 23050238, Free PMC Article
    5. Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins. Fromont-Racine M, et al. Yeast, 2000 Jun 30. PMID 10900456, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular monoatomic cation homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative amidotransferase
    NP_013227.1
    • Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      394765..395520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182013.1 → NP_013227.1  TPA: putative amidotransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013227.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYC1, Q12288
      UniProtKB/TrEMBL
      A7A125, B3LT87, B5VN57, C7GQC9, C8ZD95, G2WIW5, N1NZP3
      Conserved Domains (1) summary
      cd01741
      Location:5 → 200
      GATase1_1; Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12288.1

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