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    VBA5 basic amino acid transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VBA5
    Official Full Name
    basic amino acid transporter
    Primary source
    SGD:S000001813
    Locus tag
    YKR105C
    See related
    AllianceGenome:SGD:S000001813; FungiDB:YKR105C; VEuPathDB:YKR105C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transmembrane transporter activity. Involved in L-arginine transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VBA5 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (658716..660464, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative multidrug transporter NFT1 Neighboring gene uncharacterized protein Neighboring gene glutathione exchanger

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vba5p, a novel plasma membrane protein involved in amino acid uptake and drug sensitivity in Saccharomyces cerevisiae. Shimazu M, et al. Biosci Biotechnol Biochem, 2012. PMID 23047103
    2. Emergence of species-specific transporters during evolution of the hemiascomycete phylum. De Hertogh B, et al. Genetics, 2006 Feb. PMID 16118182, Free PMC Article
    3. A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. Shimazu M, et al. J Biol Chem, 2005 Feb 11. PMID 15572352
    4. Iterative carotenogenic screens identify combinations of yeast gene deletions that enhance sclareol production. Trikka FA, et al. Microb Cell Fact, 2015 Apr 24. PMID 25903744, Free PMC Article
    5. Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Katju V, et al. Genome Biol, 2009. PMID 19594930, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in L-arginine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    basic amino acid transporter
    NP_013031.3
    • Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      658716..660464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179895.3 → NP_013031.3  TPA: basic amino acid transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013031.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXG6, P36172
      UniProtKB/TrEMBL
      B3LU18, N1PAP1
      Conserved Domains (1) summary
      cd17502
      Location:43 → 493
      MFS_Azr1_MDR_like; Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36172.1

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