RPS28B ribosomal 40S subunit protein S28B [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPS28B
Official Full Name: ribosomal 40S subunit protein S28B
Primary source: SGD:S000004254
Locus tag: YLR264W
See related: AllianceGenome:SGD:S000004254; FungiDB:YLR264W; VEuPathDB:YLR264W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RPS33B
Summary: A structural constituent of ribosome. Involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and ribosomal subunit export from nucleus. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 15 with mandibulofacial dysostosis. Orthologous to human RPS28 (ribosomal protein S28). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPS28B in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (673131..673334)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RPS28B mRNA acts as a scaffold promoting cis-translational interaction of proteins driving P-body assembly.
Title: RPS28B mRNA acts as a scaffold promoting cis-translational interaction of proteins driving P-body assembly.
Rps28b does not bind to the 3'-untranslated region (UTR) regulatory element in RPS28B mRNA. Instead, Edc3 is directly involved in binding the element, and Rps28b binds Edc3 and regulates its activity
Title: Yeast Edc3 targets RPS28B mRNA for decapping by binding to a 3' untranslated region decay-inducing regulatory element.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal subunit export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal 40S subunit protein S28B

NP_013366.1

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; has an extraribosomal function in autoregulation, in which Rps28Bp binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

673131..673334

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182151.1 → NP_013366.1 TPA: ribosomal 40S subunit protein S28B [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013366.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYR1, P0C0X0

UniProtKB/TrEMBL

A7A1E5, B3RHE7, C7GQX6, C8ZDM8, G2WJ89, N1P6Z4

Conserved Domains (1) summary

cd04457
Location:8 → 67

S1_S28E; S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may control ...