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    SEN1 DNA/RNA helicase SEN1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851150, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEN1
    Official Full Name
    DNA/RNA helicase SEN1
    Primary source
    SGD:S000004422
    Locus tag
    YLR430W
    See related
    AllianceGenome:SGD:S000004422; FungiDB:YLR430W; VEuPathDB:YLR430W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CIK3; NRD2
    Summary
    Enables 5'-3' DNA helicase activity; 5'-3' DNA/RNA helicase activity; and protein domain specific binding activity. Involved in several processes, including DNA metabolic process; RNA metabolic process; and cell redox homeostasis. Located in cytoplasm and replication fork. Part of Nrd1 complex. Is active in nucleus. Used to study amyotrophic lateral sclerosis type 4 and spinocerebellar ataxia with axonal neuropathy 2. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and spinocerebellar ataxia with axonal neuropathy 2. Orthologous to human SETX (senataxin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEN1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (993434..1000129)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Mag2p Neighboring gene Crn1p Neighboring gene Atg23p Neighboring gene IMP dehydrogenase IMD3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-molecule characterization of Sen1 translocation properties provides insights into eukaryotic factor-dependent transcription termination. Wang S, et al. Nucleic Acids Res, 2024 Apr 12. PMID 38261990, Free PMC Article
    2. SEN1, a positive effector of tRNA-splicing endonuclease in Saccharomyces cerevisiae. DeMarini DJ, et al. Mol Cell Biol, 1992 May. PMID 1569945, Free PMC Article
    3. Inactivation of the yeast Sen1 protein affects the localization of nucleolar proteins. Ursic D, et al. Mol Gen Genet, 1995 Dec 20. PMID 8544822
    4. The yeast SEN1 gene is required for the processing of diverse RNA classes. Ursic D, et al. Nucleic Acids Res, 1997 Dec 1. PMID 9365256, Free PMC Article
    5. Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease. Chen YZ, et al. Neurobiol Dis, 2006 Jul. PMID 16644229

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-molecule characterization of Sen1 translocation properties provides insights into eukaryotic factor-dependent transcription termination.
      Title: Single-molecule characterization of Sen1 translocation properties provides insights into eukaryotic factor-dependent transcription termination.
    2. Sen1 and Rrm3 ensure permissive topological conditions for replication termination.
      Title: Sen1 and Rrm3 ensure permissive topological conditions for replication termination.
    3. Sen1 is a key regulator of transcription-driven conflicts.
      Title: Sen1 is a key regulator of transcription-driven conflicts.
    4. Modulated termination of non-coding transcription partakes in the regulation of gene expression.
      Title: Modulated termination of non-coding transcription partakes in the regulation of gene expression.
    5. Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast.
      Title: Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast.
    6. Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability.
      Title: Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability.
    7. Termination of non-coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD-mimicking region in Sen1.
      Title: Termination of non-coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD-mimicking region in Sen1.
    8. Three sequence motifs in Sen1 that mediate direct interactions with the RNA polymerase II CTD interaction domain (CID) of Nrd1 have been identified.
      Title: Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1.
    9. A harmless head-on replication-transcription clash resolution requires the fine-tuning of origin firing and coordination among Sen1, Exo1, Mre11 and Mrc1-Ctf4 complexes.
      Title: Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription.
    10. RNA polymerase II CTD tyrosine 1 is required for efficient termination by the Nrd1-Nab3-Sen1 pathway by slowing down transcription and suppressing termination defects.
      Title: RNA Polymerase II CTD Tyrosine 1 Is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-3' DNA/RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein domain specific binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription termination site sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication maintenance of fidelity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA-templated transcription termination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sno(s)RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase II transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of RNA polymerase II transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase III transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription-coupled nucleotide-excision repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Nrd1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA/RNA helicase SEN1
    NP_013534.3
    • ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      993434..1000129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182318.3 → NP_013534.3  TPA: DNA/RNA helicase SEN1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013534.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ65, E9P9Z4, Q00416, Q06448
      UniProtKB/TrEMBL
      B3RHT9, N1P7F6
      Conserved Domains (2) summary
      COG1112
      Location:1006 → 1858
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam12726
      Location:106 → 859
      SEN1_N; SEN1 N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00416.2

    Gene LinkOut

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