FRE4 ferric-chelate reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FRE4
Official Full Name: ferric-chelate reductase
Primary source: SGD:S000005343
Locus tag: YNR060W
See related: AllianceGenome:SGD:S000005343; FungiDB:YNR060W; VEuPathDB:YNR060W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ferric-chelate reductase activity. Involved in siderophore transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FRE4 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (739951..742110)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ferric-chelate reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables ferric-chelate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferric-chelate reductase activity	IEA Inferred from Electronic Annotation more info
enables ferric-chelate reductase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ferric-chelate reductase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in siderophore transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: ferric-chelate reductase

NP_014458.1

EC 1.16.1.9

Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

739951..742110

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183237.1 → NP_014458.1 TPA: ferric-chelate reductase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014458.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1N5, P53746

UniProtKB/TrEMBL

B3LPI3, C7GIY5, C8ZFT9

Conserved Domains (3) summary

cd06186
Location:428 → 596

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam08030
Location:530 → 699

NAD_binding_6; Ferric reductase NAD binding domain

pfam01794
Location:276 → 389

Ferric_reduct; Ferric reductase like transmembrane component