Ces2e carboxylesterase 2E [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ces2eprovided by RGD
Official Full Name: carboxylesterase 2Eprovided by RGD
Primary source: RGD:621563
See related: EnsemblRapid:ENSRNOG00000011635 AllianceGenome:RGD:621563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ces5
Summary: Enables retinyl-palmitate esterase activity. Predicted to be involved in retinoid metabolic process. Located in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 137.6) See more
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Genomic context

Location:: 19p14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (163899..179274)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (157447..172822)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (85679..100386)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity	IEA Inferred from Electronic Annotation more info
enables carboxylesterase activity	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables retinyl-palmitate esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables trans-permethrin hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in retinoid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pyrethroid hydrolase Ces2e

Names: carboxylesterase 5; carboxylic ester hydrolase; phenobarbital-inducible carboxylesterase (liver)

NP_001093947.1

EC 3.1.1.88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100477.1 → NP_001093947.1 pyrethroid hydrolase Ces2e precursor

See identical proteins and their annotated locations for NP_001093947.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

G3V7J5, O35535

UniProtKB/TrEMBL

A6JXT7

Related

ENSRNOP00000015724.5, ENSRNOT00000015724.9

Conserved Domains (2) summary

COG0657
Location:127 → 230

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:30 → 536

COesterase; Carboxylesterase family