SYT1 Arf family guanine nucleotide exchange factor SYT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SYT1
Official Full Name: Arf family guanine nucleotide exchange factor SYT1
Primary source: SGD:S000006299
Locus tag: YPR095C
See related: AllianceGenome:SGD:S000006299; FungiDB:YPR095C; VEuPathDB:YPR095C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of ARF protein signal transduction; protein localization to Golgi apparatus; and response to endoplasmic reticulum stress. Located in Golgi membrane. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities; lung adenocarcinoma; and non-syndromic X-linked intellectual disability 1. Orthologous to several human genes including FBXO8 (F-box protein 8); IQSEC1 (IQ motif and Sec7 domain ArfGEF 1); and IQSEC2 (IQ motif and Sec7 domain ArfGEF 2). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ARF protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ARF protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

NP_015420.1

Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain