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    OCA6 protein-tyrosine-phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OCA6
    Official Full Name
    protein-tyrosine-phosphatase
    Primary source
    SGD:S000002474
    Locus tag
    YDR067C
    See related
    AllianceGenome:SGD:S000002474; FungiDB:YDR067C; VEuPathDB:YDR067C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OCA6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (582791..583465, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Rrg1p Neighboring gene putative protein-serine/threonine phosphatase Neighboring gene Dos2p Neighboring gene ubiquitin-specific protease DOA4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide screen identifies new set of genes for improved heterologous laccase expression in Saccharomyces cerevisiae. Strawn G, et al. Microb Cell Fact, 2024 Jan 29. PMID 38287338, Free PMC Article
    2. Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Tan SX, et al. Mol Biol Cell, 2009 Mar. PMID 19129474, Free PMC Article
    3. Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms. Romá-Mateo C, et al. Mol Genet Genomics, 2011 Apr. PMID 21409566
    4. Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Kushner DB, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14671320, Free PMC Article
    5. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Armakola M, et al. Nat Genet, 2012 Dec. PMID 23104007, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-tyrosine-phosphatase
    NP_010352.1
    • Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      582791..583465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180375.1 → NP_010352.1  TPA: protein-tyrosine-phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010352.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS53, Q12454, Q6Q559
      UniProtKB/TrEMBL
      A6ZY32, B3LGK3, C7GVR9, C8Z4Y5, G2WAH1, N1P4L8
      Conserved Domains (1) summary
      cd17663
      Location:4 → 181
      PFA-DSP_Oca6; atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12454.1

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