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    PFA5 palmitoyltransferase PFA5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852070, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PFA5
    Official Full Name
    palmitoyltransferase PFA5
    Primary source
    SGD:S000002867
    Locus tag
    YDR459C
    See related
    AllianceGenome:SGD:S000002867; FungiDB:YDR459C; VEuPathDB:YDR459C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables palmitoyltransferase activity. Involved in protein palmitoylation. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PFA5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1382319..1383443, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase TOM1 Neighboring gene Heh2p Neighboring gene TFIIH/NER complex subunit TFB3 Neighboring gene mating pheromone a

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. Smotrys JE, et al. J Cell Biol, 2005 Sep 26. PMID 16186255, Free PMC Article
    2. Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Bartels DJ, et al. Mol Cell Biol, 1999 Oct. PMID 10490616, Free PMC Article
    3. Purification and characterization of recombinant protein acyltransferases. Budde C, et al. Methods, 2006 Oct. PMID 17012026, Free PMC Article
    4. Molecular recognition of the palmitoylation substrate Vac8 by its palmitoyltransferase Pfa3. Nadolski MJ, et al. J Biol Chem, 2009 Jun 26. PMID 19416974, Free PMC Article
    5. Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. Valdez-Taubas J, et al. EMBO J, 2005 Jul 20. PMID 15973437, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell periphery HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    palmitoyltransferase PFA5
    NP_010747.1
    • Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1382319..1383443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180767.1 → NP_010747.1  TPA: palmitoyltransferase PFA5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010747.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT83, Q03289
      UniProtKB/TrEMBL
      A6ZZ49, B3LFK6, B5VGZ1, C7GKQ0, C8Z617, G2WBI9, N1P7J4
      Conserved Domains (1) summary
      COG5273
      Location:9 → 335
      COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03289.1

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