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    RGI1 Rgi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RGI1
    Official Full Name
    Rgi1p
    Primary source
    SGD:S000000869
    Locus tag
    YER067W
    See related
    AllianceGenome:SGD:S000000869; FungiDB:YER067W; VEuPathDB:YER067W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in energy reserve metabolic process. Located in cell periphery. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RGI1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (292066..292551)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene Rrt13p Neighboring gene CCR4-NOT core ubiquitin-protein ligase subunit MOT2 Neighboring gene bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance. Domitrovic T, et al. PLoS One, 2010 Jun 17. PMID 20567505, Free PMC Article
    2. Identification of human ferritin, heavy polypeptide 1 (FTH1) and yeast RGI1 (YER067W) as pro-survival sequences that counteract the effects of Bax and copper in Saccharomyces cerevisiae. Eid R, et al. Exp Cell Res, 2016 Mar 1. PMID 26886577
    3. Proteomic analysis of recombinant Saccharomyces cerevisiae upon iron deficiency induced via human H-ferritin production. Seo HY, et al. J Microbiol Biotechnol, 2008 Aug. PMID 18756096
    4. Creation of a Low-Alcohol-Production Yeast by a Mutated SPT15 Transcription Regulator Triggers Transcriptional and Metabolic Changes During Wine Fermentation. Du Q, et al. Front Microbiol, 2020. PMID 33381093, Free PMC Article
    5. Construction of Saccharomyces cerevisiae strains with enhanced ethanol tolerance by mutagenesis of the TATA-binding protein gene and identification of novel genes associated with ethanol tolerance. Yang J, et al. Biotechnol Bioeng, 2011 Aug. PMID 21437883

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rgi1p is a novel pro-survival protein whose function is not related to ferritin but nevertheless it may have a role in regulating yeast sensitivity to iron stress.
      Title: Identification of human ferritin, heavy polypeptide 1 (FTH1) and yeast RGI1 (YER067W) as pro-survival sequences that counteract the effects of Bax and copper in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in energy reserve metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in energy reserve metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rgi1p
    NP_010990.1
    • Protein involved in energy metabolism under respiratory conditions; abundance is increased upon intracellular iron depletion or in response to DNA replication stress; suppresses pro-apoptotic effect of expressing human BAX in yeast cells; RGI1 has a paralog, RGI2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      292066..292551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178958.1 → NP_010990.1  TPA: Rgi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010990.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZR21, B3LRI4, C7GRP9, C8Z773, D3DLX2, P40043
      UniProtKB/TrEMBL
      G2WCV6, N1P6Z3
      Conserved Domains (1) summary
      pfam10843
      Location:21 → 157
      RGI1; Respiratory growth induced protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40043.1

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