U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TDA2 Tda2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856802, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TDA2
    Official Full Name
    Tda2p
    Primary source
    SGD:S000000873
    Locus tag
    YER071C
    See related
    AllianceGenome:SGD:S000000873; FungiDB:YER071C; VEuPathDB:YER071C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to actin filament binding activity. Involved in negative regulation of actin filament polymerization. Located in actin cortical patch. Part of Aim21-Tda2 complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TDA2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (301947..302327, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase Neighboring gene ribonucleotide-diphosphate reductase subunit RNR1 Neighboring gene Vtc1p Neighboring gene aldehyde dehydrogenase (NAD(P)(+)) ALD5

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis. Lamb AK, et al. Mol Biol Cell, 2021 Aug 1. PMID 34081539, Free PMC Article
    2. Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis. Farrell KB, et al. J Cell Biol, 2017 Aug 7. PMID 28706108, Free PMC Article
    3. New Regulators of Clathrin-Mediated Endocytosis Identified in Saccharomyces cerevisiae by Systematic Quantitative Fluorescence Microscopy. Farrell KB, et al. Genetics, 2015 Nov. PMID 26362318, Free PMC Article
    4. Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables. Shin M, et al. Mol Biol Cell, 2018 Apr 15. PMID 29467252, Free PMC Article
    5. Genome-wide analysis of the effects of heat shock on a Saccharomyces cerevisiae mutant with a constitutively activated cAMP-dependent pathway. Jones DL, et al. Comp Funct Genomics, 2004. PMID 18629174, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis.
      Title: The dynein light chain protein Tda2 functions as a dimerization engine to regulate actin capping protein during endocytosis.
    2. Aim21/Tda2 functions to reduce barbed end actin assembly. Loss of the cortical patch protein Aim21 suppresses the growth defect of tpm1 cells.
      Title: Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.
    3. Tda2 is a novel protein of the endocytic machinery necessary for normal internalization of native cargo in yeast.
      Title: Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of actin filament polymerization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Aim21-Tda2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Tda2p
    NP_010994.3
    • Subunit of a complex that associates with actin filaments; forms a complex with Aim21p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; TcTex1-type dynein light chain family member; null mutant is sensitive to expression of the top1-T722A allele

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      301947..302327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178962.3 → NP_010994.3  TPA: Tda2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010994.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZR25, B3LRI8, C7GRQ3, C8Z779, D3DLX6, P40045
      UniProtKB/TrEMBL
      G2WCW0, N1P567
      Conserved Domains (1) summary
      cd21457
      Location:5 → 124
      DLC-like_TDA2; dynein light chain (DLC)-like domain found in topoisomerase I damage affected protein 2 (TDA2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40045.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools