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    ACT1 actin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ACT1
    Official Full Name
    actin
    Primary source
    SGD:S000001855
    Locus tag
    YFL039C
    See related
    AllianceGenome:SGD:S000001855; FungiDB:YFL039C; VEuPathDB:YFL039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ABY1; END7
    Summary
    Enables ATP hydrolysis activity. A structural constituent of cytoskeleton. Involved in several processes, including ascospore wall assembly; mitotic actomyosin contractile ring contraction; and vacuole inheritance. Located in actin cytoskeleton. Part of Ino80 complex; NuA4 histone acetyltransferase complex; and Swr1 complex. Used to study Baraitser-Winter syndrome 1; artery disease (multiple); autosomal dominant nonsyndromic deafness 20; intestinal atresia; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in several diseases, including Baraitser-Winter syndrome 1; Baraitser-Winter syndrome 2; artery disease (multiple); congenital myopathy (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ACT1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    2
    Sequence:
    Chromosome: VI; NC_001138.5 (53260..54696, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene ferroxidase FET5 Neighboring gene uncharacterized protein Neighboring gene Rab family GTPase YPT1 Neighboring gene beta-tubulin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effect of the substitution of muscle actin-specific subdomain 1 and 2 residues in yeast actin on actin function. McKane M, et al. J Biol Chem, 2006 Oct 6. PMID 16882670
    2. His(73), often methylated, is an important structural determinant for actin. A mutagenic analysis of HIS(73) of yeast actin. Yao X, et al. J Biol Chem, 1999 Dec 24. PMID 10601317
    3. Role of the N-terminal negative charges of actin in force generation and cross-bridge kinetics in reconstituted bovine cardiac muscle fibres. Lu X, et al. J Physiol, 2005 Apr 1. PMID 15649975, Free PMC Article
    4. Differences in structural dynamics of muscle and yeast actin accompany differences in functional interactions with myosin. Prochniewicz E, et al. Biochemistry, 1999 Nov 9. PMID 10555968
    5. A highly conserved 3-methylhistidine modification is absent in yeast actin. Kalhor HR, et al. Arch Biochem Biophys, 1999 Oct 1. PMID 10496983

    See all (570) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.
      Title: Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.
    2. Mechanical stiffness of reconstituted actin patches correlates tightly with endocytosis efficiency.
      Title: Mechanical stiffness of reconstituted actin patches correlates tightly with endocytosis efficiency.
    3. The authors show that the type-I myosins Myo3 and Myo5 promote, in a dose-dependent way, the growth and expansion of the actin network, which controls the speed of membrane and coat internalization.
      Title: Type-I myosins promote actin polymerization to drive membrane bending in endocytosis.
    4. Act1 protein affects tombusvirus recombination in yeast .
      Title: Screening a yeast library of temperature-sensitive mutants reveals a role for actin in tombusvirus RNA recombination.
    5. Using multi-color total internal reflection fluorescence microscopy, the study shows that Crn1 enhances Cof1-mediated severing by accelerating Cof1 binding to actin filament sides.
      Title: Coronin Enhances Actin Filament Severing by Recruiting Cofilin to Filament Sides and Altering F-Actin Conformation.
    6. Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2alpha phosphorylation.
      Title: Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2α phosphorylation.
    7. Heat shock-induced processing of actin assembly protein Lsb1 is involved in prion inheritance.
      Title: Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.
    8. Data suggest that a glycolytic multi-enzyme complex assembles in cytoplasm of S. cerevisiae in association with F-actin (filamentous actin) but not in association with G-actin (monomeric globular actin).
      Title: A glycolytic metabolon in Saccharomyces cerevisiae is stabilized by F-actin.
    9. Lsb1 and/or Lsb2 full-length proteins inhibit Las17-mediated actin polymerization
      Title: Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis.
    10. data suggest that the R256H actin mutation alters filament conformation resulting in filament instability and misregulation by formin
      Title: Thoracic aortic aneurysm (TAAD)-causing mutation in actin affects formin regulation of polymerization.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ascospore wall assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin
    NP_116614.1
    • Actin, structural protein in cytoskeleton; involved in cell polarization, endocytosis, and other cytoskeletal functions; monomeric actin in the nucleus plays a role in INO80 chromatin remodeling

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      53260..54696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179927.1 → NP_116614.1  TPA: actin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116614.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTJ1, P60010, Q9P3X6, Q9P3X7
      UniProtKB/TrEMBL
      A7A200, B3LUH2, C8Z7P3, E9P9M3, G2WDA2, N1PA17
      Conserved Domains (1) summary
      cl17037
      Location:1 → 375
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60010.1

    Gene LinkOut

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