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    Ppp1r12c protein phosphatase 1, regulatory subunit 12C [ Mus musculus (house mouse) ]

    Gene ID: 232807, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppp1r12cprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 12Cprovided by MGI
    Primary source
    MGI:MGI:1924258
    See related
    Ensembl:ENSMUSG00000019254 AllianceGenome:MGI:1924258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mbs85; B430101M08; 2410197A17Rik
    Summary
    Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be involved in neuron projection morphogenesis. Predicted to be located in stress fiber. Predicted to be active in cytoplasm. Is expressed in limb mesenchyme. Orthologous to human PPP1R12C (protein phosphatase 1 regulatory subunit 12C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 29.1), lung adult (RPKM 21.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp1r12c in Genome Data Viewer
    Location:
    7 A1; 7 2.59 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4484518..4506762, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4481519..4503763, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E1718 Neighboring gene retinol dehydrogenase 13 (all-trans and 9-cis) Neighboring gene STARR-positive B cell enhancer ABC_E9682 Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene EPS8-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4461475-4461662 Neighboring gene troponin T1, skeletal, slow Neighboring gene troponin I, cardiac 3 Neighboring gene dynein, axonemal assembly factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Actin cytoskeleton remodeling primes RIG-I-like receptor activation. Acharya D, et al. Cell, 2022 Sep 15. PMID 36113429, Free PMC Article
    2. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article
    3. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
    4. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Chiang DY, et al. Circulation, 2018 Oct 9. PMID 29669786, Free PMC Article
    5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 12C
    Names
    myosin-binding subunit 85
    protein phosphatase 1 myosin-binding subunit of 85 kDa
    protein phosphatase 1 myosin-binding subunit p85
    protein phosphatase 1, regulatory (inhibitor) subunit 12C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419228.1 → NP_001406157.1  protein phosphatase 1 regulatory subunit 12C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161218
      Related
      ENSMUSP00000120029.2, ENSMUST00000124248.8

    2. NM_001419230.1 → NP_001406159.1  protein phosphatase 1 regulatory subunit 12C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161218

    3. NM_029834.4 → NP_084110.2  protein phosphatase 1 regulatory subunit 12C isoform 1

      See identical proteins and their annotated locations for NP_084110.2

      Status: VALIDATED

      Source sequence(s)
      AC161218
      Consensus CDS
      CCDS39735.1
      UniProtKB/Swiss-Prot
      Q3UMT1, Q9CWD5
      UniProtKB/TrEMBL
      F6XWD4
      Related
      ENSMUSP00000013886.9, ENSMUST00000013886.9
      Conserved Domains (5) summary
      cd00204
      Location:99 → 283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:109 → 261
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:264 → 312
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:683 → 781
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:104 → 135
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4484518..4506762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250502.3 → XP_011248804.1  protein phosphatase 1 regulatory subunit 12C isoform X2

      UniProtKB/TrEMBL
      F6XWD4
      Conserved Domains (5) summary
      COG0666
      Location:1 → 175
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      PRK12678
      Location:361 → 550
      PRK12678; transcription termination factor Rho; Provisional
      sd00045
      Location:83 → 114
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:88 → 140
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:537 → 635
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    RNA

    1. XR_881691.3 RNA Sequence

    2. XR_391056.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UMT1.1 GenPept UniProtKB/Swiss-Prot:Q3UMT1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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