IRC24 sepiapterin reductase family protein IRC24 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IRC24
Official Full Name: sepiapterin reductase family protein IRC24
Primary source: SGD:S000001475
Locus tag: YIR036C
See related: AllianceGenome:SGD:S000001475; FungiDB:YIR036C; VEuPathDB:YIR036C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables benzil reductase [(S)-benzoin-forming] activity and oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor. Located in cytoplasm. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See IRC24 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (422074..422865, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables benzil reductase [(S)-benzoin-forming] activity	IDA Inferred from Direct Assay more info	PubMed
enables benzil reductase [(S)-benzoin-forming] activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed

General protein information

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Preferred Names: sepiapterin reductase family protein IRC24

NP_012302.3

EC 1.1.1.320

Benzil oxidoreductase with preference for NADPH; localizes to the cytoplasm; induced by the DNA-damaging agent MMS; null mutant has elevated levels of spontaneous Rad52p foci; sequence similarity with short-chain dehydrogenase/reductases; putative paralog of IRC24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

422074..422865 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179558.3 → NP_012302.3 TPA: sepiapterin reductase family protein IRC24 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012302.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVW7, P40580, Q54AB5

UniProtKB/TrEMBL

A6ZVV6, B3LTH4, C7GLS0, C8ZAT8, G2WFW4, N1P4B2

Conserved Domains (1) summary

cd05367
Location:4 → 255

SPR-like_SDR_c; sepiapterin reductase (SPR)-like, classical (c) SDRs