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    CHM7 Chm7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CHM7
    Official Full Name
    Chm7p
    Primary source
    SGD:S000003585
    Locus tag
    YJL049W
    See related
    AllianceGenome:SGD:S000003585; FungiDB:YJL049W; VEuPathDB:YJL049W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidic acid binding activity. Involved in nuclear pore complex assembly. Is active in nuclear inner membrane. Orthologous to human CHMP7 (charged multivesicular body protein 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CHM7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (345973..347325)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Irc8p Neighboring gene ATP-dependent RNA helicase MTR4 Neighboring gene Ubx6p Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chm7 recruitment to sites of nuclear pore complexes assembly is mediated by its ESCRT-II domain and the LAP2-emerin-MAN1 (LEM) family of integral inner nuclear membrane proteins, Heh1 and Heh2.
      Title: Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing.
    2. Chm7 performs a novel function at the endosomal reticulum as part of an alternative ESCRT-III complex
      Title: Evidence for a Nonendosomal Function of the Saccharomyces cerevisiae ESCRT-III-Like Protein Chm7.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chm7p
    NP_012486.3
    • Phosphatidic acid (PA)-binding nuclear envelope (NE)-specific ESCRT; homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of ESCRT-III like complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      345973..347325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181482.3 → NP_012486.3  TPA: Chm7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012486.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWD4, P47048
      UniProtKB/TrEMBL
      G2WGW8, N1P0W5
      Conserved Domains (1) summary
      cl21588
      Location:247 → 381
      Snf7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47048.1

    Gene LinkOut

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