Ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ippkprovided by MGI
Official Full Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinaseprovided by MGI
Primary source: MGI:MGI:1922928
See related: Ensembl:ENSMUSG00000021385 AllianceGenome:MGI:1922928
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: InsP6; 1810043M15Rik
Summary: Predicted to enable inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity and molecular adaptor activity. Predicted to be involved in inositol phosphate biosynthetic process and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human IPPK (inositol-pentakisphosphate 2-kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 15.4), testis adult (RPKM 4.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 25.25 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (49574673..49618050)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (49421198..49464574)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystallization and preliminary x-ray diffraction analysis of a mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase has been reported.
Title: Crystallization and Preliminary X-Ray Diffraction Analysis of a Mammal Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase.
findings have uncovered distinct features of a mammalian IP5 2-K and set the stage for investigations into protein-protein or protein-RNA interactions important for IP5 2-K function and activity
Title: The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol-pentakisphosphate 2-kinase

Names: ins(1,3,4,5,6)P5 2-kinase; insP5 2-kinase

NP_001263328.1

EC 2.7.1.158

NP_951011.1

EC 2.7.1.158

XP_017171117.1

EC 2.7.1.158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276399.2 → NP_001263328.1 inositol-pentakisphosphate 2-kinase isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is longer and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AC123954

Consensus CDS

CCDS88452.1

UniProtKB/TrEMBL

A0A217FL54

Related

ENSMUSP00000021817.10, ENSMUST00000021817.10

Conserved Domains (1) summary

pfam06090
Location:80 → 504

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
NM_199056.4 → NP_951011.1 inositol-pentakisphosphate 2-kinase isoform a

See identical proteins and their annotated locations for NP_951011.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).

Source sequence(s)

AC123954

Consensus CDS

CCDS26500.1

UniProtKB/Swiss-Prot

Q3V3Z0, Q6P1C1

UniProtKB/TrEMBL

Q05CK0

Related

ENSMUSP00000152331.2, ENSMUST00000220447.2

Conserved Domains (1) summary

pfam06090
Location:13 → 455

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

RNA

NR_075085.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon near the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC123954, AK160092, AV306360, BB619387, CD353694, DV647168

Related

ENSMUST00000220856.2
NR_165080.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC123954

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

49574673..49618050

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315628.3 → XP_017171117.1 inositol-pentakisphosphate 2-kinase isoform X1

Conserved Domains (1) summary

pfam06090
Location:13 → 201

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase