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    CDC16 anaphase promoting complex subunit CDC16 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CDC16
    Official Full Name
    anaphase promoting complex subunit CDC16
    Primary source
    SGD:S000001505
    Locus tag
    YKL022C
    See related
    AllianceGenome:SGD:S000001505; FungiDB:YKL022C; VEuPathDB:YKL022C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process; negative regulation of DNA-templated DNA replication initiation; and protein ubiquitination. Located in cytosol and nucleus. Part of anaphase-promoting complex. Orthologous to human CDC16 (cell division cycle 16). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CDC16 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (394726..397248, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Min9p Neighboring gene Ska1p Neighboring gene Mak11p Neighboring gene Spt23p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metal-binding, nucleic acid-binding finger sequences in the CDC16 gene of Saccharomyces cerevisiae. Icho T, et al. Nucleic Acids Res, 1987 Oct 26. PMID 2823230, Free PMC Article
    2. Isolation of yeast DNA replication mutants in permeabilized cells. Kuo C, et al. Proc Natl Acad Sci U S A, 1983 Nov. PMID 6356128, Free PMC Article
    3. Host function of MAK16: G1 arrest by a mak16 mutant of Saccharomyces cerevisiae. Wickner RB. Proc Natl Acad Sci U S A, 1988 Aug. PMID 3045810, Free PMC Article
    4. A novel yeast mutant that is defective in regulation of the Anaphase-Promoting Complex by the spindle damage checkpoint. Lai LA, et al. Mol Genet Genomics, 2003 Nov. PMID 12928868
    5. Mitotic transmission of artificial chromosomes in cdc mutants of the yeast, Saccharomyces cerevisiae. Palmer RE, et al. Genetics, 1990 Aug. PMID 2204582, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex subunit CDC16
    NP_012903.1
    • Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      394726..397248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179588.1 → NP_012903.1  TPA: anaphase promoting complex subunit CDC16 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012903.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXR3, P09798
      UniProtKB/TrEMBL
      A6ZZU2, B3LR62, B5VMD1, C7GRI1, G2WI08, N1P0C4
      Conserved Domains (3) summary
      TIGR02917
      Location:364 → 741
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:678 → 702
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:242 → 322
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09798.1

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