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    blow blown fuse [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35694, updated on 17-Dec-2024

    Summary

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    Official Symbol
    blowprovided by FlyBase
    Official Full Name
    blown fuseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004133
    Locus tag
    Dmel_CG1363
    See related
    AllianceGenome:FB:FBgn0004133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Blow; BLOW; CG1363; Dmel\CG1363; l(2)43Eb
    Summary
    Involved in actin cytoskeleton organization; mesoderm development; and myoblast fusion. Located in cytoplasm and podosome. Is expressed in several structures, including embryonic primordium of adult muscle precursor; larval muscle system; muscle cell; myoblast; and visceral muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See blow in Genome Data Viewer
    Location:
    43E1-43E3; 2-57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7580488..7587079, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3467993..3474584, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene boca Neighboring gene Vacuolar protein sorting 13 Neighboring gene antisense RNA:CR45130 Neighboring gene uncharacterized protein Neighboring gene scraps

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Blown fuse regulates stretching and outgrowth but not myoblast fusion of the circular visceral muscles in Drosophila. Schröter RH, et al. Differentiation, 2006 Dec. PMID 17177857
    2. Muscle development: molecules of myoblast fusion. Taylor MV. Curr Biol, 2000 Sep 7. PMID 10996092
    3. Genetic analysis of myoblast fusion: blown fuse is required for progression beyond the prefusion complex. Doberstein SK, et al. J Cell Biol, 1997 Mar 24. PMID 9087441, Free PMC Article
    4. Mergers and acquisitions: unequal partnerships in Drosophila myoblast fusion. Frasch M, et al. Cell, 2000 Jul 21. PMID 10943831
    5. Integrative analysis of the zinc finger transcription factor Lame duck in the Drosophila myogenic gene regulatory network. Busser BW, et al. Proc Natl Acad Sci U S A, 2012 Dec 11. PMID 23184988, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The dynamics of the PLS is controlled by Blown fuse (Blow), a cytoplasmic protein required for myoblast fusion but whose molecular function has been elusive.
      Title: Competition between Blown fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo.
    2. kette interacts genetically with blown fuse (blow) which is known to be required to proceed from prefusion complexes to the formation of the electron dense plaques
      Title: kette and blown fuse interact genetically during the second fusion step of myogenesis in Drosophila.
    3. a model for Blow in which this protein is involved in at least two clearly differing processes during Drosophila muscle formation, namely somatic myoblast fusion on the one hand and stretching and outgrowth of circular visceral muscles on the other.
      Title: Blown fuse regulates stretching and outgrowth but not myoblast fusion of the circular visceral muscles in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    blown fuse
    Names
    CG1363-PA
    CG1363-PB
    CG1363-PD
    blow-PA
    blow-PB
    blow-PD
    blown-fuse
    blownfuse

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7580488..7587079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165542.3 → NP_724580.1  blown fuse, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z714, H5V8E2
      Related
      FBpp0088026
      Conserved Domains (2) summary
      smart00233
      Location:206 → 307
      PH; Pleckstrin homology domain
      pfam00169
      Location:206 → 307
      PH; PH domain

    2. NM_001169602.2 → NP_001163073.2  blown fuse, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163073.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z714, H5V8E2
      Conserved Domains (2) summary
      smart00233
      Location:206 → 307
      PH; Pleckstrin homology domain
      pfam00169
      Location:206 → 307
      PH; PH domain

    3. NM_001169603.1 → NP_001163074.1  blown fuse, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGZ4, F3YDJ4
      Conserved Domains (2) summary
      smart00233
      Location:199 → 300
      PH; Pleckstrin homology domain
      pfam00169
      Location:199 → 300
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z714 A1Z714
    E1JGZ4 E1JGZ4
    P91678 P91678
    Q8MSU1 Q8MSU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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