alphaTub84D alpha-Tubulin at 84D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: alphaTub84Dprovided by FlyBase
Official Full Name: alpha-Tubulin at 84Dprovided by FlyBase
Primary source: FLYBASE:FBgn0003885
Locus tag: Dmel_CG2512
See related: AllianceGenome:FB:FBgn0003885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3t; 84D; ALPHA 84D; alpha-tub; alpha-Tub; alpha-tub84D; alpha-Tub84D; alpha-tubulin; alpha3; alpha3t; alpha84D; alphaTub; alphaTUB; alphaTub3; alphaTub84; alphaTUB84D; AlphaTub84D; aTub84D; CG2512; D.m.ALPHA-84D; Dmel\CG2512; DTA4; FBgn0003884; T; Tub; Tub1A
Summary: Enables myosin binding activity. Involved in sperm axoneme assembly. Located in perinuclear region of cytoplasm. Is expressed in several structures, including embryonic/larval esophagus; neuron projection bundle of larval ventral nerve cord; ovary; presumptive embryonic/larval central nervous system; and spermatozoon. Human ortholog(s) of this gene implicated in keratoconus; lissencephaly; lissencephaly 3; microcephaly; and visual epilepsy. Orthologous to several human genes including TUBA3C (tubulin alpha 3c) and TUBA3D (tubulin alpha 3d). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (7530753..7532732)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (3356475..3358454)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

Names: CG2512-PA; Tubulin-alpha3; alpha tubulin; alpha-Tubulin; alpha-tubulin84D; alphaT; alphaTub84D-PA; alphaTubulin 84D; alphatubulin; tubulin; tubulin alpha-3 chain; tubulin alpha3; tubulin at 84D

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The following sections contain reference sequences that belong to a specific genome build. Explain