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    CG14015 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33780, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14015provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031716
    Locus tag
    Dmel_CG14015
    See related
    AllianceGenome:FB:FBgn0031716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14015
    Summary
    Predicted to enable glycoprotein endo-alpha-1,2-mannosidase activity. Predicted to be active in Golgi membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in anxiety disorder; cocaine dependence; and panic disorder. Orthologous to human MANEA (mannosidase endo-alpha) and MANEAL (mannosidase endo-alpha like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14015 in Genome Data Viewer
    Location:
    25E5-25E6; 2-17 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5536850..5539196, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5536850..5539196, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Chromosome associated protein D3 Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q6 Neighboring gene tombola Neighboring gene Helicase at 25E Neighboring gene Lamin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always early. Jiang J, et al. Development, 2007 Apr. PMID 17360778, Free PMC Article
    2. Drosophila auditory organ genes and genetic hearing defects. Senthilan PR, et al. Cell, 2012 Aug 31. PMID 22939627
    3. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article
    4. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Arya GH, et al. Chem Senses, 2015 May. PMID 25687947, Free PMC Article
    5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycoprotein endo-alpha-1,2-mannosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14015-PA
    NP_608937.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5536850..5539196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135093.4 → NP_608937.1  uncharacterized protein Dmel_CG14015 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608937.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYI8, Q9VMQ2
      Related
      FBpp0078757
      Conserved Domains (1) summary
      cl01529
      Location:130 → 453
      GH99_GH71_like; Glycoside hydrolase families 71, 99, and related domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMQ2 Q9VMQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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