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    tbrd-1 testis-specifically expressed bromodomain containing protein-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbrd-1provided by FlyBase
    Official Full Name
    testis-specifically expressed bromodomain containing protein-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039124
    Locus tag
    Dmel_CG13597
    See related
    AllianceGenome:FB:FBgn0039124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13597; Dmel\CG13597; tBrd-1; tBRD-1
    Summary
    Enables chromatin binding activity. Involved in spermatid differentiation. Located in chromosome; nuclear body; and nucleolus. Part of precatalytic spliceosome. Is expressed in primary spermatocyte; spermatocyte; and testis. Human ortholog(s) of this gene implicated in juvenile myoclonic epilepsy; lymphoma (multiple); male infertility (multiple); and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2); BRD3 (bromodomain containing 3); and BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tbrd-1 in Genome Data Viewer
    Location:
    95C8-95C9; 3-81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23891597..23893560, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19717319..19719105, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pellino Neighboring gene Transcription-factor-IIA-S Neighboring gene pseudo Neighboring gene six-banded Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes. Kimura S, et al. Open Biol, 2015 Feb. PMID 25652540, Free PMC Article
    2. Nejire/dCBP-mediated histone H3 acetylation during spermatogenesis is essential for male fertility in Drosophila melanogaster. Hundertmark T, et al. PLoS One, 2018. PMID 30192860, Free PMC Article
    3. The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility. Leser K, et al. Biol Open, 2012 Jun 15. PMID 23213453, Free PMC Article
    4. Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. Hundertmark T, et al. PLoS One, 2019. PMID 30845228, Free PMC Article
    5. A Drosophila toolkit for defining gene function in spermatogenesis. Siddall NA, et al. Reproduction, 2017 Apr. PMID 28073824

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data confirmed that tBRD-1 controls gene activity in male germ cells.
      Title: tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    testis-specifically expressed bromodomain containing protein-1
    Names
    CG13597-PA
    CG13597-PB
    tbrd-1-PA
    tbrd-1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23891597..23893560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382023.1 → NP_001369030.1  testis-specifically expressed bromodomain containing protein-1, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q058W2, Q9VCG6
      Conserved Domains (1) summary
      cl02556
      Location:39 → 143
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    2. NM_142933.2 → NP_651190.1  testis-specifically expressed bromodomain containing protein-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651190.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q058W2, Q9VCG6
      Related
      FBpp0083911
      Conserved Domains (1) summary
      cl02556
      Location:39 → 143
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCG6 Q9VCG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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