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    alphaTub67C alpha-Tubulin at 67C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alphaTub67Cprovided by FlyBase
    Official Full Name
    alpha-Tubulin at 67Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0087040
    Locus tag
    Dmel_CG8308
    See related
    AllianceGenome:FB:FBgn0087040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4t; 67C; ALPHA 67C; alpha-tub; alpha-Tub; alpha-tub67C; alpha-Tub67C; alpha-tubulin; alpha-Tubulin67C; alpha-tubulin[4]; alpha4; alpha4-t; alpha4-tubulin; alpha4t; alpha4Tub67C; alpha67C; alphatub; alphaTub; alphaTUB; alphaTub 67C; alphaTub4; alphatub67C; alphaTubulin; alphaTub[67C]; aTub67C; CG8308; D.m.ALPHA-67C; Dmel\CG8308; DTA2; Fs(3)Kav; Fs(3)Kavar; Fs(3)Sz14; Fs(3)Sz22; Fs(3)Tom; Fs(3)Tomaj; gamma-Tub; Kavar; mum-tub67C; T; Tom; tub; Tub; Tub1E; tub67c; tubulin
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including embryonic cleavage; microtubule cytoskeleton organization; and nervous system development. Located in cortical microtubule and perinuclear region of cytoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; germline cell; larval muscle cell; mesoderm; and neurogenic region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alphaTub67C in Genome Data Viewer
    Location:
    67C4-67C4; 3-31 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9681268..9683370)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9674368..9676470)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene furry Neighboring gene CNMamide Receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphoribosyl pyrophosphate synthetase Neighboring gene antisense RNA:CR45804

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo RNA localization of I factor, a non-LTR retrotransposon, requires a cis-acting signal in ORF2 and ORF1 protein. Seleme MC, et al. Nucleic Acids Res, 2005. PMID 15687386, Free PMC Article
    2. In vivo analysis of MT-based vesicle transport by confocal reflection microscopy. Gáspár I, et al. Cell Motil Cytoskeleton, 2009 Feb. PMID 19130480
    3. Reorganization of the cytoskeleton during Drosophila oogenesis: implications for axis specification and intercellular transport. Theurkauf WE, et al. Development, 1992 Aug. PMID 1451668
    4. Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration. Cliffe A, et al. Nat Commun, 2017 Apr 4. PMID 28374738, Free PMC Article
    5. alpha4-Tubulin is involved in rapid formation of long microtubules to push apart the daughter centrosomes during earlyx Drosophila embryogenesis. Venkei Z, et al. J Cell Sci, 2006 Aug 1. PMID 16847053

    See all (276) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alpha-Tubulin Regulates the Fate of Germline Stem Cells in Drosophila Testis.
      Title: α-Tubulin Regulates the Fate of Germline Stem Cells in Drosophila Testis.
    2. Glu426 is involved in stabilization of the microtubule-kinesin complexes when the kinesins are in the most labile, ADP-bound state.
      Title: Glu415 in the alpha-tubulins plays a key role in stabilizing the microtubule-ADP-kinesin complexes.
    3. Data show that alpha4-tubulin is enriched in the long microtubules that embrace the nuclear envelope and suggest that they push apart daughter centrosomes along the nuclear perimeter during the initial cleavage divisions.
      Title: alpha4-Tubulin is involved in rapid formation of long microtubules to push apart the daughter centrosomes during earlyx Drosophila embryogenesis.
    4. The Kavar(D) dominant female-sterile mutations reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.
      Title: The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female pronucleus assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pronuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm aster formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cortical microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    alpha-Tubulin at 67C
    Names
    CG8308-PA
    alpha tubulin
    alpha tubulin 67C
    alpha-Tubulin
    alpha4-tubulin
    alphaT
    alphaTub67C-PA
    alphaTubulin 67C
    alphaTubulin67C
    alphatubulin
    female sterile (3) kavar
    kavar
    tomaj
    tubulin
    tubulin at 67C
    tubulin67C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9681268..9683370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079285.4 → NP_524009.2  alpha-Tubulin at 67C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524009.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P06606, Q9VT30
      Related
      FBpp0076122
      Conserved Domains (1) summary
      cd02186
      Location:2 → 446
      alpha_tubulin; The alpha-tubulin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06606.1 P06606

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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