bab1 bric a brac 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bab1provided by FlyBase
Official Full Name: bric a brac 1provided by FlyBase
Primary source: FLYBASE:FBgn0004870
Locus tag: Dmel_CG9097
See related: AllianceGenome:FB:FBgn0004870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.639; bab; BAB; BAB-1; bab-I; Bab1; BAB1; bric; bric-a-brac; CG13910; CG9097; Dmel\CG9097
Summary: Enables minor groove of adenine-thymine-rich DNA binding activity. Involved in eye-antennal disc morphogenesis; leg disc morphogenesis; and sex differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; gut section; imaginal disc; organism subdivision; and somatic cell of ovariole. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61E2-61F1; 3-0.5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1036369..1101089, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1036369..1101089, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Bric-a-Brac BTB/POZ transcription factors are necessary in niche cells for germline stem cells establishment and homeostasis through control of BMP/DPP signaling in the Drosophila melanogaster ovary.
Title: The Bric-à-Brac BTB/POZ transcription factors are necessary in niche cells for germline stem cells establishment and homeostasis through control of BMP/DPP signaling in the Drosophila melanogaster ovary.
Genetic variation at the bab locus affects bab expression and female abdominal pigmentation. Expression levels vary with temperature, participate in the pigmentation difference between the Dark and Pale lines.
Title: bric à brac (bab), a central player in the gene regulatory network that mediates thermal plasticity of pigmentation in Drosophila melanogaster.
In Drosophila melanogaster, dimorphic pigmentation is controlled by the dimorphic expression of the paralogous Bab1 and Bab2 transcription factors that repress pigmentation.
Title: The evolution of Bab paralog expression and abdominal pigmentation among Sophophora fruit fly species.
whereas the bab locus controls the sorting of TFCs into TFs, psq plays a major function in global control of TFC number, without affecting sorting of TFCs into TFs.
Title: Genetic basis for developmental homeostasis of germline stem cell niche number: a network of Tramtrack-Group nuclear BTB factors.
Sequence variation at the bric a brac (bab) locus of Drosophila melanogaster, was examined.
Title: Contrasting patterns of sequence evolution at the functionally redundant bric à brac paralogs in Drosophila melanogaster.
The tissue distribution of Bab1 and Bab2 overlaps, with Bab1 being expressed in a subpattern of Bab2.
Title: The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2291 (e-PCR)
- UniSTS:24507

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c1055161-1047496 mobile_element_type = transposon:412{}902

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables minor groove of adenine-thymine-rich DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in eye-antennal disc morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in female sex differentiation	TAS Traceable Author Statement more info	PubMed
involved_in leg disc morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of developmental pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of male pigmentation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of developmental pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex differentiation	TAS Traceable Author Statement more info	PubMed
involved_in sex-specific pigmentation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bric a brac 1

Names: Bric-a-brac; CG9097-PB; CG9097-PC; CG9097-PD; CG9097-PE; bab1-PB; bab1-PC; bab1-PD; bab1-PE; bric a brac; bric a brac I; bric a brac1; bric-a-brac 1; bric-a-brac1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1036369..1101089 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274310.1 → NP_001261239.1 bric a brac 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261239.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PE50

Conserved Domains (3) summary

smart00225
Location:128 → 213

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:117 → 216

BTB; BTB/POZ domain

pfam05225
Location:568 → 613

HTH_psq; helix-turn-helix, Psq domain
NM_001274312.1 → NP_001261241.1 bric a brac 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261241.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGP8

Conserved Domains (3) summary

smart00225
Location:128 → 213

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:117 → 216

BTB; BTB/POZ domain

pfam05225
Location:568 → 613

HTH_psq; helix-turn-helix, Psq domain
NM_001274311.1 → NP_001261240.1 bric a brac 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261240.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PDT5

Conserved Domains (3) summary

smart00225
Location:128 → 213

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:117 → 216

BTB; BTB/POZ domain

pfam05225
Location:569 → 614

HTH_psq; helix-turn-helix, Psq domain
NM_167852.2 → NP_728565.1 bric a brac 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728565.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23968, Q8MR78, Q9U1H7, Q9W0K7

Related

FBpp0072538

Conserved Domains (3) summary

smart00225
Location:128 → 213

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:117 → 216

BTB; BTB/POZ domain

pfam05225
Location:569 → 614

HTH_psq; helix-turn-helix, Psq domain