U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    CanB2 Calcineurin B2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46456, updated on 9-Dec-2024

    Summary

    Official Symbol
    CanB2provided by FlyBase
    Official Full Name
    Calcineurin B2provided by FlyBase
    Primary source
    FLYBASE:FBgn0015614
    Locus tag
    Dmel_CG11217
    See related
    AllianceGenome:FB:FBgn0015614
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CaN; canB2; CaNB2; CG11217; CS2-1; dCnB2; dCNB2; Dmel\CG11217
    Summary
    Predicted to enable several functions, including calcium ion binding activity; calcium-dependent protein serine/threonine phosphatase regulator activity; and calmodulin binding activity. Involved in meiotic cell cycle; sarcomere organization; and sleep. Predicted to be part of calcineurin complex. Is expressed in several structures, including adult brain; adult optic lobe; embryonic/larval midgut primordium; gut section; and larval muscle system. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to several human genes including PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CanB2 in Genome Data Viewer
    Location:
    43E16-43E16; 2-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7786010..7789053)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3673515..3676558)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45108 Neighboring gene mir-4980 stem loop Neighboring gene cinnabar Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables calcium-dependent protein serine/threonine phosphatase regulator activity  
    enables calcium-dependent protein serine/threonine phosphatase regulator activity  
    enables calcium-dependent protein serine/threonine phosphatase regulator activity PubMed 
    enables calmodulin binding PubMed 
    enables phosphatase binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling  
    involved_in meiotic cell cycle PubMed 
    involved_in neurotransmitter secretion PubMed 
    involved_in sarcomere organization PubMed 
    involved_in sleep PubMed 
    involved_in vesicle-mediated transport PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex  
    part_of calcineurin complex PubMed 
    located_in synaptic vesicle PubMed 

    General protein information

    Preferred Names
    calcineurin B2
    Names
    CG11217-PA
    CG11217-PB
    CanB2-PA
    CanB2-PB
    calcineurin suppressor, chromosome 2, group 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7786010..7789053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259263.2 → NP_001246192.1  calcineurin B2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24214, Q9V315
      UniProtKB/TrEMBL
      A0A0B4K833
      Conserved Domains (1) summary
      COG5126
      Location:13 → 154
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    2. NM_080135.4 → NP_524874.2  calcineurin B2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524874.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24214, Q9V315
      UniProtKB/TrEMBL
      A0A0B4K833
      Related
      FBpp0088004
      Conserved Domains (1) summary
      COG5126
      Location:13 → 154
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    External link. Please review our privacy policy.