lush lush [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lushprovided by FlyBase
Official Full Name: lushprovided by FlyBase
Primary source: FLYBASE:FBgn0020277
Locus tag: Dmel_CG8807
See related: AllianceGenome:FB:FBgn0020277
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 76a; 76c; 76c(LUSH); CG8807; DmelObp76a; DmelOBP76a; Dmel\CG8807; Lush; LUSH; OBP LUSH; obp76a; Obp76a; OBP76a; Obp76a (LUSH)
Summary: Enables dibutyl phthalate binding activity and diphenyl phthalate binding activity. Involved in several processes, including courtship behavior; olfactory behavior; and sensory perception of smell. Located in extracellular region. Is expressed in antenna; antennal sense organ; eo sensory organ accessory cell; and trichoid sensillum. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 76B9-76B9; 3-45 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19604398..19606090, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19597498..19599190, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An angiotensin converting enzyme homolog is required for volatile pheromone detection, odorant binding protein secretion and normal courtship behavior in Drosophila melanogaster.
Title: An angiotensin converting enzyme homolog is required for volatile pheromone detection, odorant binding protein secretion and normal courtship behavior in Drosophila melanogaster.
the ligand-binding cavity of LUSH protein can accommodate a variety ligands and pheromones with strong binding interactions
Title: Quantitative analysis of pheromone-binding protein specificity.
the alcohol binding in the LUSH protein is the consequence of three important factors: H-bonding, solvation, and the other noncovalent interaction.
Title: Alcohol binding to the odorant binding protein LUSH: multiple factors affecting binding affinities.
Detection of odorants by olfactory neurons is results from direct activation of odorant receptors by odor molecules; study shows that detection of the 11-cis vaccenyl acetate (cVA), is instead mediated by pheromone-induced conformational shifts in LUSH.
Title: Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein.
genetic interaction between lush and spontaneous activity in 11-cis vaccenyl acetate-sensitive neurons in the absence of pheromone
Title: Drosophila OBP LUSH is required for activity of pheromone-sensitive neurons.
LUSH, a soluble odorant-binding protein, undergoes a major conformational change, triggered by ligands.
Title: Revisiting the odorant-binding protein LUSH of Drosophila melanogaster: evidence for odour recognition and discrimination.
Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster
Title: Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables dibutyl phthalate binding	IBA Inferred from Biological aspect of Ancestor more info
enables dibutyl phthalate binding	IDA Inferred from Direct Assay more info	PubMed
enables diphenyl phthalate binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables ethanol binding	IDA Inferred from Direct Assay more info	PubMed
enables odorant binding	IEA Inferred from Electronic Annotation more info
enables odorant binding	NAS Non-traceable Author Statement more info	PubMed
enables odorant binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in olfactory behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	TAS Traceable Author Statement more info	PubMed
involved_in response to pheromone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lush

Names: CG8807-PA; CG8807-PB; LUSH; lush-PA; lush-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19604398..19606090 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079438.3 → NP_524162.1 lush, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524162.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JI39, O02372, Q29QG4

UniProtKB/TrEMBL

A0A1B2AJ65

Related

FBpp0074737

Conserved Domains (1) summary

smart00708
Location:42 → 145

PhBP; Insect pheromone/odorant binding protein domains
NM_001169997.1 → NP_001163468.1 lush, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163468.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JI39, O02372, Q29QG4

UniProtKB/TrEMBL

A0A1B2AJ65

Conserved Domains (1) summary

smart00708
Location:42 → 145

PhBP; Insect pheromone/odorant binding protein domains