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    Cog2 Component of oligomeric golgi complex 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41870, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cog2provided by FlyBase
    Official Full Name
    Component of oligomeric golgi complex 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0026634
    Locus tag
    Dmel_CG6177
    See related
    AllianceGenome:FB:FBgn0026634
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6177; Dmel\CG6177; ldl-Cp; ldlCp
    Summary
    Involved in dsRNA transport. Part of Golgi transport complex. Is expressed in several structures, including gland; gut section; and salivary gland body primordium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIq. Orthologous to human COG2 (component of oligomeric golgi complex 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cog2 in Genome Data Viewer
    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15358481..15361657, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11184203..11187379, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TRAPP subunit 33 Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene Autophagy-related 4b Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase Neighboring gene Translin associated factor X Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of Drosophila Translin and Trax. Claussen M, et al. Genetics, 2006 Nov. PMID 17028328, Free PMC Article
    2. Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Smith RD, et al. Carbohydr Res, 2008 Aug 11. PMID 18353293, Free PMC Article
    3. Genetic and molecular analysis of region 88E9;88F2 in Drosophila melanogaster, including the ear gene related to human factors involved in lineage-specific leukemias. Zraly CB, et al. Genetics, 2002 Mar. PMID 11901121, Free PMC Article
    4. The loss of Drosophila APG4/AUT2 function modifies the phenotypes of cut and Notch signaling pathway mutants. Thumm M, et al. Mol Genet Genomics, 2001 Dec. PMID 11810238
    5. An endogenous small interfering RNA pathway in Drosophila. Czech B, et al. Nature, 2008 Jun 5. PMID 18463631, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    component of oligomeric golgi complex 2
    Names
    CG6177-PA
    Cog2-PA
    ldlCp-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15358481..15361657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079642.3 → NP_524366.1  component of oligomeric golgi complex 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524366.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZC5, Q9VF78, Q9XZ52
      Related
      FBpp0082568
      Conserved Domains (2) summary
      pfam06148
      Location:22 → 154
      COG2; COG (conserved oligomeric Golgi) complex component, COG2
      pfam12022
      Location:546 → 672
      DUF3510; Domain of unknown function (DUF3510)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF78.1 Q9VF78

    Gene LinkOut

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