raptor raptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: raptorprovided by FlyBase
Official Full Name: raptorprovided by FlyBase
Primary source: FLYBASE:FBgn0029840
Locus tag: Dmel_CG4320
See related: AllianceGenome:FB:FBgn0029840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 4320; CG4320; Dmel\CG4320; dRap; dRaptor; dRAPTOR; Raptor; raptor/CG4320
Summary: Predicted to enable protein-macromolecule adaptor activity. Involved in several processes, including TORC1 signaling; determination of adult lifespan; and insulin receptor signaling pathway. Part of TORC1 complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 5D4-5D4; 1-15 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6082634..6090201, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5976667..5984234, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

REPTOR and REPTOR-BP play critical roles in maintaining energy homeostasis and promoting animal survival upon nutrient restriction
Title: REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1.
We found that neither S6K-dependent cell growth nor S6K-Thr-398 phosphorylation was affected in rictor-null mutants.
Title: Discrete functions of rictor and raptor in cell growth regulation in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eclosion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: raptor

Names: CG4320-PB; CG4320-PC; RAPTOR; TORC1; dRaptor; raptor-PB; raptor-PC; target of rapamycin (TOR)-associated protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

6082634..6090201 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001297995.1 → NP_001284924.1 raptor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284924.1

Status: REVIEWED

UniProtKB/TrEMBL

C3KKC3, Q9W437

Conserved Domains (6) summary

COG2319
Location:1296 → 1617

WD40; WD40 repeat [General function prediction only]

pfam13646
Location:743 → 847

HEAT_2; HEAT repeats

pfam14538
Location:219 → 365

Raptor_N; Raptor N-terminal CASPase like domain

sd00044
Location:612 → 634

HEAT; HEAT repeat [structural motif]

sd00039
Location:1448 → 1489

7WD40; WD40 repeat [structural motif]

cl02567
Location:1400 → 1617

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_132066.2 → NP_572294.2 raptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572294.2

Status: REVIEWED

UniProtKB/TrEMBL

C3KKC3, Q9W437

Conserved Domains (6) summary

COG2319
Location:1296 → 1617

WD40; WD40 repeat [General function prediction only]

pfam13646
Location:743 → 847

HEAT_2; HEAT repeats

pfam14538
Location:219 → 365

Raptor_N; Raptor N-terminal CASPase like domain

sd00044
Location:612 → 634

HEAT; HEAT repeat [structural motif]

sd00039
Location:1448 → 1489

7WD40; WD40 repeat [structural motif]

cl02567
Location:1400 → 1617

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...