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    Bcat Branched chain amino acid transaminase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32297, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bcatprovided by FlyBase
    Official Full Name
    Branched chain amino acid transaminaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030482
    Locus tag
    Dmel_CG1673
    See related
    AllianceGenome:FB:FBgn0030482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bcat; BCAT; BCAT1; cg1673; CG1673; Dmel\CG1673
    Summary
    Enables L-isoleucine-2-oxoglutarate transaminase activity; L-leucine-2-oxoglutarate transaminase activity; and L-valine-2-oxoglutarate transaminase activity. Involved in L-leucine catabolic process; isoleucine catabolic process; and valine catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to several human genes including BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Bcat in Genome Data Viewer
    Location:
    11F1-11F3; 1-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13396899..13401224)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13290932..13295257)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44620 Neighboring gene long non-coding RNA:CR44621 Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase T4

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-leucine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in branched-chain amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in isoleucine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in valine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    branched chain amino acid transaminase
    Names
    Bcat-PA
    CG1673-PA
    branched-chain amino acid aminotransferase
    NP_572884.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13396899..13401224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132656.2NP_572884.1  branched chain amino acid transaminase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYD5
      Related
      FBpp0073608
      Conserved Domains (2) summary
      PRK13357
      Location:82443
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:138432
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...