CG8916 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG8916provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0030707
Locus tag: Dmel_CG8916
See related: AllianceGenome:FB:FBgn0030707
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG8916; Lcch-14A
Summary: Predicted to enable neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; alcoholic liver cirrhosis; amphetamine abuse; and epilepsy (multiple). Orthologous to several human genes including GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3); GABRA4 (gamma-aminobutyric acid type A receptor subunit alpha4); and GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 14A1-14A1; 1-52 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15921955..15924558)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15815988..15818591)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG8916-PB; CG8916-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15921955..15924558

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132862.3 → NP_573090.3 uncharacterized protein Dmel_CG8916, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573090.3

Status: REVIEWED

UniProtKB/TrEMBL

Q4V4V5, Q9VXL9

Conserved Domains (3) summary

TIGR00860
Location:92 → 598

LIC; Cation transporter family protein

pfam02931
Location:111 → 315

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:322 → 403

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001169299.2 → NP_001162770.1 uncharacterized protein Dmel_CG8916, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162770.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJA9, Q4V4W7

Conserved Domains (3) summary

TIGR00860
Location:9 → 496

LIC; Cation transporter family protein

pfam02931
Location:9 → 213

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:220 → 301

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region