Idh3a Isocitrate dehydrogenase 3a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Idh3aprovided by FlyBase
Official Full Name: Isocitrate dehydrogenase 3aprovided by FlyBase
Primary source: FLYBASE:FBgn0027291
Locus tag: Dmel_CG12233
See related: AllianceGenome:FB:FBgn0027291
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12233; dIDH3a; Dmel\CG12233; idh3a; IDH3A; l (1) G0156; l(1)G0156; lethal (1) G0156
Summary: Enables isocitrate dehydrogenase (NAD+) activity. Involved in tricarboxylic acid cycle. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; ganglia; gut section; and larval muscle cell. Used to study neuromuscular junction disease. Human ortholog(s) of this gene implicated in retinitis pigmentosa 90. Orthologous to human IDH3A (isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18C8-18C8; 1-62 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19518428..19521810, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19412461..19415843, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for isocitrate dehydrogenase 3a (idh3a), a Krebs cycle enzyme, in neurotransmission, is reported.
Title: The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables isocitrate dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in isocitrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of isocitrate dehydrogenase complex (NAD+)	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial matrix	EXP Inferred from Experiment more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: isocitrate dehydrogenase 3a

Names: CG12233-PA; CG12233-PC; CG12233-PD; Idh3a-PA; Idh3a-PC; Idh3a-PD; Lethal(1)G0156; isocitrate dehydrogenase; l(1)G0156; lethal (1) G0156

NP_001259705.1

EC 1.1.1.-

EC 1.1.1.41

NP_573388.1

EC 1.1.1.-

EC 1.1.1.41

NP_728257.2

EC 1.1.1.-

EC 1.1.1.41

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19518428..19521810 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167657.3 → NP_728257.2 isocitrate dehydrogenase 3a, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728257.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VWH4

Conserved Domains (1) summary

cl00445
Location:23 → 354

Iso_dh; Isocitrate/isopropylmalate dehydrogenase
NM_133160.2 → NP_573388.1 isocitrate dehydrogenase 3a, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_573388.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VWH4

Related

FBpp0074549

Conserved Domains (1) summary

cl00445
Location:23 → 354

Iso_dh; Isocitrate/isopropylmalate dehydrogenase
NM_001272776.1 → NP_001259705.1 isocitrate dehydrogenase 3a, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259705.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E4NKP2, Q8IQW9, Q8SXH8, Q9VWH4

Conserved Domains (1) summary

cl00445
Location:46 → 377

Iso_dh; Isocitrate/isopropylmalate dehydrogenase