U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Stt3A Catalytic subunit 3A of the oligosaccharyltransferase complex [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33082, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Stt3Aprovided by FlyBase
    Official Full Name
    Catalytic subunit 3A of the oligosaccharyltransferase complexprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031149
    Locus tag
    Dmel_CG1518
    See related
    AllianceGenome:FB:FBgn0031149
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1518; Dmel\CG1518; STT
    Summary
    Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in post-translational protein modification and protein N-linked glycosylation via asparagine. Located in endomembrane system. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iw. Orthologous to human STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Stt3A in Genome Data Viewer
    Location:
    19E7-19E7; 1-65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21049885..21053937, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20920912..20924964, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44431 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Microsomal glutathione S-transferase-like Neighboring gene small Cajal body-specific RNA : MeU2-C28 Neighboring gene Cystathionine beta-synthase Neighboring gene bves Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene stargazin-like protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolutionarily conserved and species-specific glycoproteins in the N-glycoproteomes of diverse insect species. Scheys F, et al. Insect Biochem Mol Biol, 2018 Sep. PMID 29906502
    2. Mgat1-dependent N-glycosylation of membrane components primes Drosophila melanogaster blood cells for the cellular encapsulation response. Mortimer NT, et al. PLoS Pathog, 2012. PMID 22829770, Free PMC Article
    3. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
    4. The defender against apoptotic cell death 1 gene is required for tissue growth and efficient N-glycosylation in Drosophila melanogaster. Zhang Y, et al. Dev Biol, 2016 Dec 1. PMID 27693235
    5. Analysis of cell surface proteome changes via label-free, quantitative mass spectrometry. Schiess R, et al. Mol Cell Proteomics, 2009 Apr. PMID 19036722, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligosaccharyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-translational protein modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    catalytic subunit 3A of the oligosaccharyltransferase complex
    Names
    CG1518-PA
    CG1518-PC
    Stt3A-PA
    Stt3A-PC
    NP_001259751.2
    NP_608425.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21049885..21053937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272822.2 → NP_001259751.2  catalytic subunit 3A of the oligosaccharyltransferase complex, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259751.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DN57, M9PI34, Q9VRE0
      Conserved Domains (2) summary
      COG1287
      Location:19 → 712
      Stt3; Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, protein turnover, chaperones]
      pfam02516
      Location:21 → 495
      STT3; Oligosaccharyl transferase STT3 subunit

    2. NM_134581.2 → NP_608425.1  catalytic subunit 3A of the oligosaccharyltransferase complex, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DN57, M9PI34, Q9VRE0
      Related
      FBpp0076956
      Conserved Domains (2) summary
      COG1287
      Location:19 → 712
      Stt3; Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, protein turnover, chaperones]
      pfam02516
      Location:21 → 495
      STT3; Oligosaccharyl transferase STT3 subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRE0 Q9VRE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools