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    CG1598 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1598provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033191
    Locus tag
    Dmel_CG1598
    See related
    AllianceGenome:FB:FBgn0033191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM18141; BEST:GH10483; Dmel\CG1598; gh10483
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in tail-anchored membrane protein insertion into ER membrane. Predicted to be part of GET complex. Is expressed in several structures, including Malpighian tubule primordium; adult head; dorsal ectoderm; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human GET3 (guided entry of tail-anchored proteins factor 3, ATPase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1598 in Genome Data Viewer
    Location:
    43D3-43D3; 2-56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7538232..7539696, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3425737..3427201, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44209 Neighboring gene Cytochrome b5 Neighboring gene Glycerophosphate oxidase 2 Neighboring gene corin Neighboring gene Ribulose-5-phosphate-3-epimerase Neighboring gene boca

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autocrine insulin pathway signaling regulates actin dynamics in cell wound repair. Nakamura M, et al. PLoS Genet, 2020 Dec. PMID 33306674, Free PMC Article
    2. Ultrasensitive proteome analysis using paramagnetic bead technology. Hughes CS, et al. Mol Syst Biol, 2014 Oct 30. PMID 25358341, Free PMC Article
    3. Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Zou S, et al. Proc Natl Acad Sci U S A, 2000 Dec 5. PMID 11095759, Free PMC Article
    4. The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: implications for the regulation of energy metabolism. Pile LA, et al. J Biol Chem, 2003 Sep 26. PMID 12865422
    5. siRNA screen identifies QPCT as a druggable target for Huntington's disease. Jimenez-Sanchez M, et al. Nat Chem Biol, 2015 May. PMID 25848931, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tail-anchored membrane protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1598-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7538232..7539696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136452.3 → NP_610296.2  uncharacterized protein Dmel_CG1598 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610296.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JWD3, Q8SZC0
      Related
      FBpp0088029
      Conserved Domains (2) summary
      COG0003
      Location:37 → 330
      ArsA; Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism]
      pfam02374
      Location:21 → 326
      ArsA_ATPase; Anion-transporting ATPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JWD3.1 Q7JWD3
    Q8IH28 Q8IH28

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