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    Vps20 Vacuolar protein sorting 20 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37581, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps20provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 20provided by FlyBase
    Primary source
    FLYBASE:FBgn0034744
    Locus tag
    Dmel_CG4071
    See related
    AllianceGenome:FB:FBgn0034744
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey40; CG4071; Dmel\CG4071; DmVPS20; ESCRT-III; vps20
    Summary
    Involved in endosome transport via multivesicular body sorting pathway and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Orthologous to human CHMP6 (charged multivesicular body protein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps20 in Genome Data Viewer
    Location:
    58F1-58F2; 2-100 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22608310..22609419)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18495815..18496924)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S16 Neighboring gene testes of unusual size Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclin-dependent kinase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleoporins are degraded via upregulation of ESCRT-III/Vps4 complex in Drosophila models of C9-ALS/FTD. Dubey SK, et al. Cell Rep, 2022 Sep 20. PMID 36130523, Free PMC Article
    2. The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms. Bäumers M, et al. Biol Open, 2019 Sep 2. PMID 31412999, Free PMC Article
    3. The mapping of Drosophila melanogaster mutant A.4.4. Bieser K, et al. MicroPubl Biol, 2018 Dec 17. PMID 32550366, Free PMC Article
    4. The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4. Troost T, et al. J Cell Sci, 2012 Feb 1. PMID 22389409
    5. Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery. Baeumers M, et al. BMC Biol, 2020 Dec 22. PMID 33349255, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT III complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting 20
    Names
    CG4071-PA
    CG4071-PC
    Vps20-PA
    Vps20-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22608310..22609419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137842.3 → NP_611686.2  vacuolar protein sorting 20, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611686.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKK3, Q9W236
      Conserved Domains (1) summary
      pfam03357
      Location:22 → 186
      Snf7; Snf7

    2. NM_166536.3 → NP_726213.1  vacuolar protein sorting 20, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E4NKK3, Q9W236
      Related
      FBpp0071767
      Conserved Domains (1) summary
      pfam03357
      Location:22 → 186
      Snf7; Snf7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SY83 Q8SY83
    Q9W236 Q9W236

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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