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    ZC3H3 ZC3H3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38968, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZC3H3provided by FlyBase
    Official Full Name
    ZC3H3provided by FlyBase
    Primary source
    FLYBASE:FBgn0035900
    Locus tag
    Dmel_CG6694
    See related
    AllianceGenome:FB:FBgn0035900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6694; Dmel\CG6694; dZC3H3
    Summary
    Predicted to enable metal ion binding activity. Involved in nuclear export and regulation of mRNA export from nucleus. Located in nucleus. Orthologous to human ZC3H3 (zinc finger CCCH-type containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ZC3H3 in Genome Data Viewer
    Location:
    66D4-66D5; 3-26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8507469..8509763, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8500569..8502863, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Grunge Neighboring gene uncharacterized protein Neighboring gene Pseudouridine synthase 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export. Hurt JA, et al. J Cell Biol, 2009 Apr 20. PMID 19364924, Free PMC Article
    2. Definition of global and transcript-specific mRNA export pathways in metazoans. Farny NG, et al. Genes Dev, 2008 Jan 1. PMID 18086857, Free PMC Article
    3. The effects of natural selection across molecular pathways in Drosophila melanogaster. Vedanayagam JP, et al. BMC Evol Biol, 2015 Sep 21. PMID 26391223, Free PMC Article
    4. The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance. Ariyapala IS, et al. Genetics, 2022 Sep 30. PMID 35762963, Free PMC Article
    5. A neurogenetic mechanism of experience-dependent suppression of aggression. Ishii K, et al. Sci Adv, 2022 Sep 9. PMID 36070378, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ZC3H3
    Names
    CG6694-PA
    ZC3H3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8507469..8509763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139973.3 → NP_648230.1  ZC3H3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648230.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VSK8
      Related
      FBpp0076380
      Conserved Domains (2) summary
      smart00356
      Location:425 → 447
      ZnF_C3H1; zinc finger
      COG5084
      Location:329 → 519
      YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSK8.2 Q9VSK8

    Gene LinkOut

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